WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H597369
CAS#: 134186-26-8
Description: KF 14124 showed potent anti-ischemic activity in a lysine-vasopressin-induced angina pectoris model (rats).
Hodoodo Cat#: H597369
Name: KF 14124
CAS#: 134186-26-8
Chemical Formula: C19H27N3O5S
Exact Mass: 409.17
Molecular Weight: 409.500
Elemental Analysis: C, 55.73; H, 6.65; N, 10.26; O, 19.53; S, 7.83
This product is not in stock, which may be available by custom synthesis.
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Synonym: KF 14124; KF-14124; KF14124; Dptpp-2-ismn;
IUPAC/Chemical Name: (3S,3aS,6S,6aR)-6-(4-(3-(phenylthio)propyl)piperazin-1-yl)hexahydrofuro[3,2-b]furan-3-yl nitrate
InChi Key: IHHFECHILHHROD-INDMIFKZSA-N
InChi Code: InChI=1S/C19H27N3O5S/c23-22(24)27-17-14-26-18-16(13-25-19(17)18)21-10-8-20(9-11-21)7-4-12-28-15-5-2-1-3-6-15/h1-3,5-6,16-19H,4,7-14H2/t16-,17-,18+,19+/m0/s1
SMILES Code: O=[N+]([O-])O[C@H]1CO[C@H]2[C@@H]1OC[C@@H]2N(CC3)CCN3CCCSc4ccccc4
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 409.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Hayashi H, Ikeda J, Kubo K, Moriyama T, Karasawa A, Suzuki F. 1,4:3,6-Dianhydrohexitol nitrate derivatives. II. Synthesis and antianginal activity of aryl- or arylcarbonylpiperazine derivatives. Chem Pharm Bull (Tokyo). 1993 Jun;41(6):1100-10. PubMed PMID: 8370110.
2: Hayashi H, Ikeda J, Kuroda T, Kubo K, Sano T, Suzuki F. 1,4:3,6-Dianhydrohexitol nitrate derivatives. I. Synthesis and antianginal activity of alkylpiperazine derivatives. Chem Pharm Bull (Tokyo). 1993 Jun;41(6):1091-9. PubMed PMID: 8370109.