WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H597392
CAS#: 141024-74-0
Description: Trichodecenin I is a peptaibol isolated from Trichoderma viride.
Hodoodo Cat#: H597392
Name: Trichodecenin I
CAS#: 141024-74-0
Chemical Formula: C38H69N7O8
Exact Mass: 751.52
Molecular Weight: 752.010
Elemental Analysis: C, 60.69; H, 9.25; N, 13.04; O, 17.02
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Synonym: Trichodecenin I; 4-Decenoyl-gly-gly-leu-aib-gly-ile-lol; Trichodecenin-I;
IUPAC/Chemical Name: (Z)-N-((7S,16S,19S)-16-((S)-sec-butyl)-19-(hydroxymethyl)-7-isobutyl-10,10,21-trimethyl-2,5,8,11,14,17-hexaoxo-3,6,9,12,15,18-hexaazadocosyl)dec-4-enamide
InChi Key: BJULECFFERYMOK-GABKIWGSSA-N
InChi Code: InChI=1S/C38H69N7O8/c1-10-12-13-14-15-16-17-18-30(47)39-21-31(48)40-22-32(49)43-29(20-26(5)6)35(51)45-38(8,9)37(53)41-23-33(50)44-34(27(7)11-2)36(52)42-28(24-46)19-25(3)4/h15-16,25-29,34,46H,10-14,17-24H2,1-9H3,(H,39,47)(H,40,48)(H,41,53)(H,42,52)(H,43,49)(H,44,50)(H,45,51)/b16-15-/t27-,28-,29-,34-/m0/s1
SMILES Code: CC[C@@H]([C@H](NC(CNC(C(C)(NC([C@@H](NC(CNC(CNC(CC/C=C\CCCCC)=O)=O)=O)CC(C)C)=O)C)=O)=O)C(N[C@H](CO)CC(C)C)=O)C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 752.01 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Gatto E, Bocchinfuso G, Palleschi A, Oncea S, De Zotti M, Formaggio F, Toniolo C, Venanzi M. 3D structure, dynamics, and activity of synthetic analog of the peptaibiotic trichodecenin I. Chem Biodivers. 2013 May;10(5):887-903. doi: 10.1002/cbdv.201200388. PubMed PMID: 23681732.
2: Monaco V, Formaggio F, Crisma M, Toniolo C, Shui X, Eggleston DS. Crystallographic structure of a multiple beta-turn containing, glycine-rich heptapeptide: a synthetic precursor of the lipopeptaibol antibiotic trichodecenin I. Biopolymers. 1996 Jul;39(1):31-42. PubMed PMID: 8924625.
3: Fujita T, Wada S, Iida A, Nishimura T, Kanai M, Toyama N. Fungal metabolites. XIII. Isolation and structural elucidation of new peptaibols, trichodecenins-I and -II, from Trichoderma viride. Chem Pharm Bull (Tokyo). 1994 Mar;42(3):489-94. PubMed PMID: 8004694.
4: Toniolo C, Crisma M, Formaggio F, Peggion C, Epand RF, Epand RM. Lipopeptaibols, a novel family of membrane active, antimicrobial peptides. Cell Mol Life Sci. 2001 Aug;58(9):1179-88. Review. PubMed PMID: 11577977.