WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H597436
CAS#: 852243-39-1
Description: WT-1 A1 is an attractive target for immunotherapy in patients with pancreatic adenocarcinoma.
Hodoodo Cat#: H597436
Name: WT-1 A1
CAS#: 852243-39-1
Chemical Formula: C55H74N10O13S
Exact Mass: 1,114.52
Molecular Weight: 1,115.310
Elemental Analysis: C, 59.23; H, 6.69; N, 12.56; O, 18.65; S, 2.87
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: WT-1 A1; Tyr-Met-Phe-Pro-agn-Ala-Pro-Tyr-Leu;
IUPAC/Chemical Name: L-Leucine, L-tyrosyl-L-methionyl-L-phenylalanyl-L-prolyl-L-asparaginyl-L-alanyl-L-prolyl-L-tyrosyl-
InChi Key: IBNSYSWDJJQKSY-PJYANRIDSA-N
InChi Code: InChI=1S/C55H74N10O13S/c1-31(2)26-43(55(77)78)63-50(72)40(28-35-16-20-37(67)21-17-35)60-51(73)44-12-8-23-64(44)53(75)32(3)58-49(71)41(30-46(57)68)61-52(74)45-13-9-24-65(45)54(76)42(29-33-10-6-5-7-11-33)62-48(70)39(22-25-79-4)59-47(69)38(56)27-34-14-18-36(66)19-15-34/h5-7,10-11,14-21,31-32,38-45,66-67H,8-9,12-13,22-30,56H2,1-4H3,(H2,57,68)(H,58,71)(H,59,69)(H,60,73)(H,61,74)(H,62,70)(H,63,72)(H,77,78)/t32-,38-,39-,40-,41-,42-,43-,44-,45-/m0/s1
SMILES Code: CC(C)C[C@@H](C(O)=O)NC([C@H](CC1=CC=C(O)C=C1)NC([C@H]2N(C([C@H](C)NC([C@H](CC(N)=O)NC([C@H]3N(C([C@H](CC4=CC=CC=C4)NC([C@H](CCSC)NC([C@H](CC5=CC=C(O)C=C5)N)=O)=O)=O)CCC3)=O)=O)=O)CCC2)=O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 1,115.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Terashima T, Mizukoshi E, Arai K, Yamashita T, Yoshida M, Ota H, Onishi I, Kayahara M, Ohtsubo K, Kagaya T, Honda M, Kaneko S. P53, hTERT, WT-1, and VEGFR2 are the most suitable targets for cancer vaccine therapy in HLA-A24 positive pancreatic adenocarcinoma. Cancer Immunol Immunother. 2014 May;63(5):479-89. doi: 10.1007/s00262-014-1529-8. Epub 2014 Mar 16. PubMed PMID: 24633336.
2: Asma GE, van den Bergh RL, Vossen JM. Characterization of early lymphoid precursor cells in the human fetus using monoclonal antibodies and anti-terminal deoxynucleotidyl transferase. Clin Exp Immunol. 1986 May;64(2):356-63. PubMed PMID: 3742878; PubMed Central PMCID: PMC1542329.
3: Akiyama Y, Oshita C, Kume A, Iizuka A, Miyata H, Komiyama M, Ashizawa T, Yagoto M, Abe Y, Mitsuya K, Watanabe R, Sugino T, Yamaguchi K, Nakasu Y. α-type-1 polarized dendritic cell-based vaccination in recurrent high-grade glioma: a phase I clinical trial. BMC Cancer. 2012 Dec 27;12:623. doi: 10.1186/1471-2407-12-623. PubMed PMID: 23270484; PubMed Central PMCID: PMC3541167.
4: Adkins WK, Barnard JW, Moore TM, Allison RC, Prasad VR, Taylor AE. Adenosine prevents PMA-induced lung injury via an A2 receptor mechanism. J Appl Physiol (1985). 1993 Mar;74(3):982-8. PubMed PMID: 8387073.
5: Petrou M, Wynne DG, Boheler KR, Yacoub MH. Clenbuterol induces hypertrophy of the latissimus dorsi muscle and heart in the rat with molecular and phenotypic changes. Circulation. 1995 Nov 1;92(9 Suppl):II483-9. PubMed PMID: 7586459.
6: Seubert PA, Grant PA, Christie EA, Farley JR, Segel IH. Kinetic and chemical properties of ATP sulphurylase from Penicillin chrysogenum. Ciba Found Symp. 1979;(72):19-47. Review. PubMed PMID: 232997.
7: Stephens RH, Benjamin AR, Walters DV. The regulation of lung liquid absorption by endogenous cAMP in postnatal sheep lungs perfused in situ. J Physiol. 1998 Sep 1;511 ( Pt 2):587-97. PubMed PMID: 9706033; PubMed Central PMCID: PMC2231140.
8: Jackson AA, Phillips G, McClelland I, Jahoor F. Synthesis of hepatic secretory proteins in normal adults consuming a diet marginally adequate in protein. Am J Physiol Gastrointest Liver Physiol. 2001 Nov;281(5):G1179-87. PubMed PMID: 11668026.
9: Koos BJ, Chau A. Fetal cardiovascular and breathing responses to an adenosine A2a receptor agonist in sheep. Am J Physiol. 1998 Jan;274(1 Pt 2):R152-9. PubMed PMID: 9458912.
10: Adler AJ, Zara C, Berlyne GM. Effect of aluminum on bidirectional calcium flux in rat everted intestinal sacs. Am J Physiol. 1989 Sep;257(3 Pt 1):G433-7. PubMed PMID: 2782413.
11: Mohamed YS, Dunnion D, Teobald I, Walewska R, Browning MJ. Long-lived fusions of human haematological tumour cells and B-lymphoblastoid cells induce tumour antigen-specific cytotoxic T-cell responses in vitro. Immunobiology. 2012 Jul;217(7):719-29. doi: 10.1016/j.imbio.2011.12.001. Epub 2011 Dec 8. PubMed PMID: 22305004.
12: Poock SR, Leach ER, Moir JW, Cole JA, Richardson DJ. Respiratory detoxification of nitric oxide by the cytochrome c nitrite reductase of Escherichia coli. J Biol Chem. 2002 Jun 28;277(26):23664-9. Epub 2002 Apr 17. PubMed PMID: 11960983.
