Ketopioglitazone
featured

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H558353

CAS#: 146062-45-5

Description: Ketopioglitazone is an active metabolite of pioglitazone and is found in human plasma.

Chemical Structure

img
Ketopioglitazone
CAS# 146062-45-5
Instruction

Theoretical Analysis

Hodoodo Cat#: H558353
Name: Ketopioglitazone
CAS#: 146062-45-5
Chemical Formula: C19H18N2O4S
Exact Mass: 370.10
Molecular Weight: 370.420
Elemental Analysis: C, 61.61; H, 4.90; N, 7.56; O, 17.28; S, 8.65

Price and Availability

Size Price Availability Quantity
5mg USD 1150 2 Weeks
Bulk inquiry

Synonym: Ketopioglitazone; Keto pioglitazone; Pioglitazone metabolite M3;

IUPAC/Chemical Name: 5-(4-(2-(5-acetylpyridin-2-yl)ethoxy)benzyl)thiazolidine-2,4-dione

InChi Key: JMLKLMFMQRAJNI-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H18N2O4S/c1-12(22)14-4-5-15(20-11-14)8-9-25-16-6-2-13(3-7-16)10-17-18(23)21-19(24)26-17/h2-7,11,17H,8-10H2,1H3,(H,21,23,24)

SMILES Code: O=C(N1)SC(CC2=CC=C(OCCC3=NC=C(C(C)=O)C=C3)C=C2)C1=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 370.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Kawaguchi-Suzuki M, Bril F, Sanchez PP, Cusi K, Frye RF. A validated liquid chromatography tandem mass spectrometry method for simultaneous determination of pioglitazone, hydroxypioglitazone, and ketopioglitazone in human plasma and its application to a clinical study. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Oct 15;969:219-23. doi: 10.1016/j.jchromb.2014.08.019. Epub 2014 Aug 21. PubMed PMID: 25195022.

2: Vaidyanathan S, Maboudian M, Warren V, Yeh CM, Dieterich HA, Howard D, Dole WP. A study of the pharmacokinetic interactions of the direct renin inhibitor aliskiren with metformin, pioglitazone and fenofibrate in healthy subjects. Curr Med Res Opin. 2008 Aug;24(8):2313-26. doi: 10.1185/03007990802259354. PubMed PMID: 18786303.