WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H461004
CAS#: 192185-68-5
Description: R 115777 is a farnesyl transferase inhibitor.
Hodoodo Cat#: H461004
Name: R 115777
CAS#: 192185-68-5
Chemical Formula: C27H22Cl2N4O
Exact Mass: 488.12
Molecular Weight: 489.400
Elemental Analysis: C, 66.26; H, 4.53; Cl, 14.49; N, 11.45; O, 3.27
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Synonym: R 115777; R-115777; R115777
IUPAC/Chemical Name: 2(1H)-Quinolinone, 6-(amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methyl-
InChi Key: PLHJCIYEEKOWNM-UHFFFAOYSA-N
InChi Code: InChI=1S/C27H22Cl2N4O/c1-32-16-31-15-25(32)27(30,18-6-9-20(28)10-7-18)19-8-11-24-23(13-19)22(14-26(34)33(24)2)17-4-3-5-21(29)12-17/h3-16H,30H2,1-2H3
SMILES Code: O=C1N(C)C2=C(C=C(C(C3=CC=C(Cl)C=C3)(N)C4=CN=CN4C)C=C2)C(C5=CC=CC(Cl)=C5)=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 489.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
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4: Morgan MA, Ganser A, Reuter CW. Therapeutic efficacy of prenylation inhibitors in the treatment of myeloid leukemia. Leukemia. 2003 Aug;17(8):1482-98. Review. PubMed PMID: 12886235.
5: R-115777. Drug News Perspect. 2000 Dec;13(10):621. PubMed PMID: 12879132.
6: Dempke WC. Farnesyltransferase inhibitors--a novel approach in the treatment of advanced pancreatic carcinomas. Anticancer Res. 2003 Mar-Apr;23(2A):813-8. Review. PubMed PMID: 12820305.
7: Haller DG. Future directions in the treatment of pancreatic cancer. Semin Oncol. 2002 Dec;29(6 Suppl 20):31-9. Review. PubMed PMID: 12577231.
8: Singh SB, Lingham RB. Current progress on farnesyl protein transferase inhibitors. Curr Opin Drug Discov Devel. 2002 Mar;5(2):225-44. Review. PubMed PMID: 11926129.