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Flunarizine hydrochloride
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WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H461009

CAS#: 30484-77-6

Description: Flunarizine hydrochloride is a calcium antagonist. It has been reported to induce parkinsonism, especially in the elderly.

Chemical Structure

Flunarizine hydrochloride

CAS# 30484-77-6

Instruction

Theoretical Analysis

Hodoodo Cat#: H461009
Name: Flunarizine hydrochloride
CAS#: 30484-77-6
Chemical Formula: C26H28Cl2F2N2
Exact Mass: 0.00
Molecular Weight: 477.420
Elemental Analysis: C, 65.41; H, 5.91; Cl, 14.85; F, 7.96; N, 5.87

Price and Availability

Size	Price	Availability
1g	USD 250	2 Weeks
5g	USD 500	2 Weeks
10g	USD 650	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. Hodoodo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Flunarizine hydrochloride; Flunarizine HCl; EINECS 250-216-6; KW-3149; R 14950; R-14950; R14950

IUPAC/Chemical Name: 1-(bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine dihydrochloride

InChi Key: RXKMOPXNWTYEHI-RDRKJGRWSA-N

InChi Code: InChI=1S/C26H26F2N2.2ClH/c27-24-12-8-22(9-13-24)26(23-10-14-25(28)15-11-23)30-19-17-29(18-20-30)16-4-7-21-5-2-1-3-6-21;;/h1-15,26H,16-20H2;2*1H/b7-4+;;

SMILES Code: FC1=CC=C(C(N2CCN(C/C=C/C3=CC=CC=C3)CC2)C4=CC=C(F)C=C4)C=C1.[H]Cl.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Instruction:

View handling instruction

Biological target:	Flunarizine dihydrochloride is a potent dual Na+/Ca2+ channel (T-type) blocker.
In vitro activity:	Application of FLN (flunarizine) produced a significant cytotoxic effect on U-87 MG (Fig. 1A), LN-229 (Fig. 1B), and U-118 MG (Fig. 1C) cells. The results of cell survival and colony formation assay suggested that FLN exhibited anti-proliferation activity in GBM cells. Reference: Eur J Pharmacol. 2021 Feb 5;892:173756. https://pubmed.ncbi.nlm.nih.gov/33245897/
In vivo activity:	The flunarizine treatment significantly extended lifespan of ≈40% with a shift in mean survival of SMA mice (16.3 versus 11.7 days; Mantel-Cox test, p = 0.0002). Reference: Sci Rep. 2018; 8: 2075. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794986/

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	23.2	48.53
	DMSO:PBS (pH 7.2) (1:2)	0.3	0.69
	DMF	1.0	2.09
	Ethanol	2.0	4.19
	Water	1.0	2.09

Preparing Stock Solutions

The following data is based on the product molecular weight 477.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:	1. Kim HJ, Lee J, Lee GR, Kim N, Lee HI, Kwon M, Kim NY, Park JH, Kang YH, Song HJ, Kim T, Shin DM, Jeong W. Flunarizine inhibits osteoclastogenesis by regulating calcium signaling and promotes osteogenesis. J Cell Physiol. 2021 Jun 30. doi: 10.1002/jcp.30496. Epub ahead of print. PMID: 34192358. 2. Chen SH, Chao CN, Chen SY, Lin HP, Huang HY, Fang CY. Flunarizine, a drug approved for treating migraine and vertigo, exhibits cytotoxicity in GBM cells. Eur J Pharmacol. 2021 Feb 5;892:173756. doi: 10.1016/j.ejphar.2020.173756. Epub 2020 Nov 25. PMID: 33245897. 3. Sapaly D, Dos Santos M, Delers P, Biondi O, Quérol G, Houdebine L, Khoobarry K, Girardet F, Burlet P, Armand AS, Chanoine C, Bureau JF, Charbonnier F, Lefebvre S. Small-molecule flunarizine increases SMN protein in nuclear Cajal bodies and motor function in a mouse model of spinal muscular atrophy. Sci Rep. 2018 Feb 1;8(1):2075. doi: 10.1038/s41598-018-20219-1. PMID: 29391529; PMCID: PMC5794986.
In vitro protocol:	1. Kim HJ, Lee J, Lee GR, Kim N, Lee HI, Kwon M, Kim NY, Park JH, Kang YH, Song HJ, Kim T, Shin DM, Jeong W. Flunarizine inhibits osteoclastogenesis by regulating calcium signaling and promotes osteogenesis. J Cell Physiol. 2021 Jun 30. doi: 10.1002/jcp.30496. Epub ahead of print. PMID: 34192358. 2. Chen SH, Chao CN, Chen SY, Lin HP, Huang HY, Fang CY. Flunarizine, a drug approved for treating migraine and vertigo, exhibits cytotoxicity in GBM cells. Eur J Pharmacol. 2021 Feb 5;892:173756. doi: 10.1016/j.ejphar.2020.173756. Epub 2020 Nov 25. PMID: 33245897.
In vivo protocol:	1. Kim HJ, Lee J, Lee GR, Kim N, Lee HI, Kwon M, Kim NY, Park JH, Kang YH, Song HJ, Kim T, Shin DM, Jeong W. Flunarizine inhibits osteoclastogenesis by regulating calcium signaling and promotes osteogenesis. J Cell Physiol. 2021 Jun 30. doi: 10.1002/jcp.30496. Epub ahead of print. PMID: 34192358. 2. Sapaly D, Dos Santos M, Delers P, Biondi O, Quérol G, Houdebine L, Khoobarry K, Girardet F, Burlet P, Armand AS, Chanoine C, Bureau JF, Charbonnier F, Lefebvre S. Small-molecule flunarizine increases SMN protein in nuclear Cajal bodies and motor function in a mouse model of spinal muscular atrophy. Sci Rep. 2018 Feb 1;8(1):2075. doi: 10.1038/s41598-018-20219-1. PMID: 29391529; PMCID: PMC5794986.

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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1: Niu J, Hu R. Role of flunarizine hydrochloride in secondary brain injury following intracerebral hemorrhage in rats. Int J Immunopathol Pharmacol. 2017 Dec;30(4):413-419. doi: 10.1177/0394632017742224. Epub 2017 Nov 22. PubMed PMID: 29164980; PubMed Central PMCID: PMC5806815.

2: Shu ZH, Wang GQ, Li MQ, Wang XG. [Clinical efficacy on vertebrobasilar insufficiency treated with auricular acupuncture]. Zhongguo Zhen Jiu. 2014 Dec;34(12):1161-4. Chinese. PubMed PMID: 25876341.

3: Sun L, Liang Y, Li X, Liu L, Xu X, Ma H, Li W, Shi Fei, Gao F. [Efficacy of acupuncture combined with auricular point sticking on the content of serum prostaglandin F2α, and plasma arginine vasopressin in patients with menstrual headache]. Zhongguo Zhen Jiu. 2015 Feb;35(2):137-40. Chinese. PubMed PMID: 25854019.

4: Sun LH, Li XH, Li WL, Liu L, Ma HL, Liang YL. [Body acupuncture combined with auricular acupressure for menstrual headache: a randomized controlled clinical trial]. Zhen Ci Yan Jiu. 2015 Feb;40(1):70-4. Chinese. PubMed PMID: 25845225.

5: Zhang H, Geng M, Yan B, Lu X. [Epley's manoeuvre versus Epley's manoeuvre plus labyrinthine sedative in the management of benign paroxysmal positional vertigo: prospective, randomised study]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2012 Aug;26(16):750-2. Chinese. PubMed PMID: 23213757.

6: Luo GG, Fan WJ, Yuan XY, Yuan BB, Lü SM, Cao YX, Xu CB. [The pharmacological mechanism of gastrodin on calcitonin gene-related peptide of cultured rat trigeminal ganglion]. Yao Xue Xue Bao. 2011 Dec;46(12):1451-6. Chinese. PubMed PMID: 22375417.

7: Jiang X, Bai Y, Ling X, Han F, Li R, Cui J. Simultaneous determination of 4-methyl-piperazine-1-carbodithioc acid 3-cyano-3,3-diphenylpropyl ester hydrochloride and its major metabolite in rats by HPLC. J Chromatogr Sci. 2010 Feb;48(2):125-9. PubMed PMID: 20109290.

8: Zhang Y, Zhang L, Li B, Wang LP. [Effects of acupuncture preventive treatment on the quality of life in patients of no-aura migraine]. Zhongguo Zhen Jiu. 2009 Jun;29(6):431-5. Chinese. PubMed PMID: 19563186.

9: Kong X, Ma F, Xin Y, Zhao Y, Li N. [Efficacy of carbamazepine combined with flunarizine hydrochloride for treating tinnitus]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2008 Nov;22(22):1016-8, 1022. Chinese. PubMed PMID: 19266814.

10: She X, Wu L, Wei H, Liu W, Chen Y. Determination of oxatomide in human plasma by high-performance liquid chromatography-electrospray ionization mass spectrometry. Biomed Chromatogr. 2008 Jul;22(7):746-52. doi: 10.1002/bmc.992. PubMed PMID: 18348338.

11: Ma FR, Xin Y, Zhao YM, Lü JQ. [Efficacy of Betahistine Mesilate combined with Flunarizine Hydrochloride for treating tinnitus]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2006 Apr;41(4):269-73. Chinese. PubMed PMID: 16848175.

12: Zheng Z, Song KY, Hu XM, Yu F, Deng XZ, Zhang Q, Wen GW, Cao XM. [Experimental study of electroacupuncture improving the obstruction of vestibular microcirculation in vertebrobasilar insufficiency and the effect on vestibulo-ocular reflex]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2006 Feb;22(1):99-104. Chinese. PubMed PMID: 21186592.

13: El-Sherbiny DT, Eid MI, El-Wasseef DR, Al-Ashan RM, Belal F. Analysis of flunarizine in the presence of some of its degradation products using micellar liquid chromatography (MLC) or microemulsion liquid chromatography (MELC)--application to dosage forms. J Sep Sci. 2005 Feb;28(2):197-202. PubMed PMID: 15754830.

14: Hu ZQ, Song LG, Mei T. [Clinical and experimental study on treatment of migraine with shutianning granule]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2002 Aug;22(8):581-3. Chinese. PubMed PMID: 12572376.

15: Kelani K, Bebawy LI, Abdel-Fattah L. Determination of astemizole, terfenadine and flunarizine hydrochloride by ternary complex formation with eosin and lead(II). J Pharm Biomed Anal. 1999 Jan;18(6):985-92. PubMed PMID: 9925333.

16: Takahashi K, Lam TT, Edward DP, Buchi ER, Tso MO. Protective effects of flunarizine on ischemic injury in the rat retina. Arch Ophthalmol. 1992 Jun;110(6):862-70. PubMed PMID: 1596236.

17: Ohshima F, Masuda Y, Kodaira M, Fukayama M, Inamatsu T, Nagura H. [A case report of severe urinary retention and meteorism during flunarizine administration]. Nihon Ronen Igakkai Zasshi. 1992 Mar;29(3):198-201. Japanese. PubMed PMID: 1593790.

18: Asanuma M, Ogawa N, Haba K, Hirata H, Mori A. Calcium antagonist flunarizine hydrochloride affects striatal D2 dopamine receptors in the young adult and aged rat brain. Arch Gerontol Geriatr. 1991 Nov-Dec;13(3):271-8. PubMed PMID: 15374420.

19: Edward DP, Lam TT, Shahinfar S, Li J, Tso MO. Amelioration of light-induced retinal degeneration by a calcium overload blocker. Flunarizine. Arch Ophthalmol. 1991 Apr;109(4):554-62. PubMed PMID: 2012559.

20: Ogawa N, Asanuma M, Takayama H, Sato H, Nukina I. [Effect of flunarizine hydrochloride on striatal D-2 dopamine receptors]. Rinsho Shinkeigaku. 1990 Nov;30(11):1221-6. Japanese. PubMed PMID: 2150791.

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Flunarizine hydrochloride featured