WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H563315
CAS#: 275374-93-1
Description: 18BIOder is a neuroprotective GSK-3β inhibitor, highly selectively inhibiting HIV-1. It is the second generation derivative of 6BIO.
Hodoodo Cat#: H563315
Name: 18BIOder
CAS#: 275374-93-1
Chemical Formula: C9H7ClN2O2
Exact Mass: 210.02
Molecular Weight: 210.610
Elemental Analysis: C, 51.32; H, 3.35; Cl, 16.83; N, 13.30; O, 15.19
This product is not in stock, which may be available by custom synthesis.
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Synonym: 18BIOder; 18-BIOder; 18 BIOder;
IUPAC/Chemical Name: 6-Chloro-7-methyl-1H-indole-2,3-dione 3-oxime
InChi Key: PNSCLWDBNGJLCG-UHFFFAOYSA-N
InChi Code: InChI=1S/C9H7ClN2O2/c1-4-6(10)3-2-5-7(4)11-9(13)8(5)12-14/h2-3,14H,1H3,(H,11,12,13)
SMILES Code: O=C1NC2=C(C=CC(Cl)=C2C)/C1=N/O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 210.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Guendel I, Iordanskiy S, Van Duyne R, Kehn-Hall K, Saifuddin M, Das R, Jaworski E, Sampey GC, Senina S, Shultz L, Narayanan A, Chen H, Lepene B, Zeng C, Kashanchi F. Novel neuroprotective GSK-3β inhibitor restricts Tat-mediated HIV-1 replication. J Virol. 2014 Jan;88(2):1189-208. doi: 10.1128/JVI.01940-13. Epub 2013 Nov 13. PubMed PMID: 24227837; PubMed Central PMCID: PMC3911635.