WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H563357
CAS#: 491878-69-4
Description: JWB1-84-1 3HCl is a neuroprotective agent that acts by improving cognitive performances in a transgenic mouse model of AD.
Hodoodo Cat#: H563357
Name: JWB1-84-1 3HCl
CAS#: 491878-69-4
Chemical Formula: C12H22Cl3N3O
Exact Mass: 0.00
Molecular Weight: 330.670
Elemental Analysis: C, 43.59; H, 6.71; Cl, 32.16; N, 12.71; O, 4.84
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Synonym: JWB1-84-1 3HCl; JWB1 84 1 3HCl; JWB1841 3HCl; JWB1-84-1 trihydrochloride; JWB1 84 1 trihydrochloride; JWB1841 trihydrochloride;
IUPAC/Chemical Name: 2-(4-(pyridin-3-ylmethyl)piperazin-1-yl)ethan-1-ol trihydrochloride
InChi Key: UFVMFIXCHOTLGR-UHFFFAOYSA-N
InChi Code: InChI=1S/C12H19N3O.3ClH/c16-9-8-14-4-6-15(7-5-14)11-12-2-1-3-13-10-12;;;/h1-3,10,16H,4-9,11H2;3*1H
SMILES Code: OCCN1CCN(CC2=CC=CN=C2)CC1.[H]Cl.[H]Cl.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
More Info:
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The following data is based on the product molecular weight 330.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Keowkase R, Aboukhatwa M, Adam BL, Beach JW, Terry AV Jr, Buccafussco JJ, Luo Y. Neuroprotective effects and mechanism of cognitive-enhancing choline analogs JWB 1-84-1 and JAY 2-22-33 in neuronal culture and Caenorhabditis elegans. Mol Neurodegener. 2010 Dec 16;5:59. doi: 10.1186/1750-1326-5-59. PubMed PMID: 21162742; PubMed Central PMCID: PMC3017027.
2: Buccafusco JJ, Beach JW, Terry AV Jr. Desensitization of nicotinic acetylcholine receptors as a strategy for drug development. J Pharmacol Exp Ther. 2009 Feb;328(2):364-70. doi: 10.1124/jpet.108.145292. Epub 2008 Nov 20. Review. PubMed PMID: 19023041; PubMed Central PMCID: PMC2682277.
3: Sood A, Warren Beach J, Webster SJ, Terry AV, Buccafusco JJ. The effects of JWB1-84-1 on memory-related task performance by amyloid Abeta transgenic mice and by young and aged monkeys. Neuropharmacology. 2007 Oct;53(5):588-600. Epub 2007 Jul 14. PubMed PMID: 17698153.
4: Buccafusco JJ. Neuronal nicotinic receptor subtypes: defining therapeutic targets. Mol Interv. 2004 Oct;4(5):285-95. Review. PubMed PMID: 15471911.
