WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H592526
CAS#: 165101-50-8
Description: Alexomycin is a thiopeptide; a cyclic peptide antibiotic produced by Streptomyces arginensis isolated from the soil.
Hodoodo Cat#: H592526
Name: Alexomycin
CAS#: 165101-50-8
Chemical Formula: C22H24Cl2N2O8
Exact Mass: 514.09
Molecular Weight: 515.340
Elemental Analysis: C, 51.28; H, 4.69; Cl, 13.76; N, 5.44; O, 24.84
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Synonym: 165101-50-8
IUPAC/Chemical Name: (4S,4aS,5aS,6S,12aS)-7-chloro-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carbimidic acid hydrochloride
InChi Key: CBHYYLPALVVVEY-MRFRVZCGSA-N
InChi Code: InChI=1S/C22H23ClN2O8.ClH/c1-21(32)7-6-8-15(25(2)3)17(28)13(20(24)31)19(30)22(8,33)18(29)11(7)16(27)12-10(26)5-4-9(23)14(12)21;/h4-5,7-8,15,26,28-29,32-33H,6H2,1-3H3,(H2,24,31);1H/t7-,8-,15-,21-,22-;/m0./s1
SMILES Code: CN([C@H]1[C@@H]2C[C@H]3C(C(c4c([C@]3(O)C)c(Cl)ccc4O)=O)=C([C@@]2(C(C(C(O)=N)=C1O)=O)O)O)C.Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 515.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Marshall SA, Jones RN. Spectrum and antimicrobial activity of alexomycin (PNU-82, 127), a peptide compound projected for use in animal health. Diagn Microbiol Infect Dis. 1999 Mar;33(3):181-6. PubMed PMID: 10092967.
2: Ashraf-Khorassani M, Taylor LT, Marr JG. Analysis of the sulfomycin component of alexomycin in animal feed by enhanced solvent extraction and supercritical fluid chromatography. J Biochem Biophys Methods. 2000 Jul 5;43(1-3):147-56. PubMed PMID: 10869673.
3: Jones RN, Chen YS, Marshall SA. Comparative in vitro activity of alexomycin (U-82127) tested against Escherichia coli, Salmonella spp., and enterococci of animal and human origin. Clin Microbiol Infect. 1998;4(10):601-603. PubMed PMID: 11864251.
4: Odland BA, Erwin ME, Jones RN. Quality control guidelines for disk diffusion and broth microdilution antimicrobial susceptibility tests with seven drugs for veterinary applications. J Clin Microbiol. 2000 Jan;38(1):453-5. PubMed PMID: 10618141; PubMed Central PMCID: PMC88749.
5: Cho BY, Strong R, Fate G, Krull IS. High-performance capillary electrophoresis of a fermentation-derived cyclic peptide analog, animal growth promoter. J Chromatogr B Biomed Sci Appl. 1997 Sep 12;697(1-2):163-74. PubMed PMID: 9342666.
6: Cromwell GL, Davis GW, Morrow WE, Primo RA, Rozeboom DW, Sims MD, Stanisiewski EP, Ho CH. Efficacy of the antimicrobial compound U-82,127 as a growth promoter for growing-finishing pigs. J Anim Sci. 1996 Jun;74(6):1284-7. PubMed PMID: 8791200.