WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H598439
CAS#: 3253-60-9
Description: Laudexium methylsulfate is a neuromuscular blocking drug or skeletal muscle relaxant in the category of non-depolarizing neuromuscular-blocking drugs, used adjunctively in surgical anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.
Hodoodo Cat#: H598439
Name: Laudexium methylsulfate
CAS#: 3253-60-9
Chemical Formula: C54H80N2O16S2
Exact Mass: 0.00
Molecular Weight: 1,077.350
Elemental Analysis: C, 60.20; H, 7.49; N, 2.60; O, 23.76; S, 5.95
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Synonym: Laudexium methylsulfate; Laudexium; Laudolissin methosulphate;
IUPAC/Chemical Name: 2,2'-(decane-1,10-diyl)bis(1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium) methyl sulfate
InChi Key: LADQAYSLFLCKOD-UHFFFAOYSA-L
InChi Code: InChI=1S/C52H74N2O8.2CH4O4S/c1-53(27-23-39-33-49(59-7)51(61-9)35-41(39)43(53)29-37-19-21-45(55-3)47(31-37)57-5)25-17-15-13-11-12-14-16-18-26-54(2)28-24-40-34-50(60-8)52(62-10)36-42(40)44(54)30-38-20-22-46(56-4)48(32-38)58-6;2*1-5-6(2,3)4/h19-22,31-36,43-44H,11-18,23-30H2,1-10H3;2*1H3,(H,2,3,4)/q+2;;/p-2
SMILES Code: COC1=CC(CC2[N+](CCCCCCCCCC[N+]3(C)C(CC4=CC=C(OC)C(OC)=C4)C5=C(C=C(OC)C(OC)=C5)CC3)(C)CCC6=C2C=C(OC)C(OC)=C6)=CC=C1OC.O=S(OC)([O-])=O.O=S(OC)([O-])=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 1,077.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: BRITTAIN RT, CHESHER BG, COLLIER HO, GRIMSHAW JJ. Assay of suxamethonium and laudexium on the frog rectus abdominis. Br J Pharmacol Chemother. 1959 Jun;14(2):158-63. PubMed PMID: 13662566; PubMed Central PMCID: PMC1481804.
2: COLLIER HO, MACAULEY B. The effects on animals of large doses of laudexium methylsulphate. Br J Anaesth. 1954 Jul;26(4):237-44. PubMed PMID: 13172370.
3: BROWN LH. Failure to detect anticholinesterase activity in laudexium methylsulphate. Br J Anaesth. 1954 Jul;26(4):244-5. PubMed PMID: 13172371.
4: HUNTER AR. The action of laudexium in man and experimental animals. Br J Anaesth. 1955 Feb;27(2):73-9. PubMed PMID: 13230365.
5: STEAD AL, ANDREWS WH. The role of the canine liver in the detoxication of d-tubocurarine chloride, gallamine triethiodide and laudexium. Br J Anaesth. 1957 Apr;29(4):151-5. PubMed PMID: 13426356.
