MCI-225

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H563523

CAS#: 135991-48-9(free base)

Description: MCI-225 is a selective NA reuptake inhibitor with 5-HT3 receptor antagonism.

Chemical Structure

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MCI-225
CAS# 135991-48-9(free base)
Instruction

Theoretical Analysis

Hodoodo Cat#: H563523
Name: MCI-225
CAS#: 135991-48-9(free base)
Chemical Formula: C17H17FN4S
Exact Mass: 328.12
Molecular Weight: 328.400
Elemental Analysis: C, 62.17; H, 5.22; F, 5.78; N, 17.06; S, 9.76

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: MCI-225; MCI 225; MCI225; DDP-225; DDP 225; DDP225;

IUPAC/Chemical Name: 4-(2-Fluorophenyl)-6-methyl-2-piperazin-1-ylthieno[2,3-d]pyrimidine

InChi Key: FVIVKIGLBDRWNR-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H17FN4S/c1-11-10-13-15(12-4-2-3-5-14(12)18)20-17(21-16(13)23-11)22-8-6-19-7-9-22/h2-5,10,19H,6-9H2,1H3

SMILES Code: CC1=CC2=C(C3=CC=CC=C3F)N=C(N4CCNCC4)N=C2S1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 328.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Schreiber S, Schreiber F, Lockhart SN, Horng A, Bejanin A, Landau SM, Jagust WJ; Alzheimer’s Disease Neuroimaging Initiative. Alzheimer Disease Signature Neurodegeneration and APOE Genotype in Mild Cognitive Impairment With Suspected Non-Alzheimer Disease Pathophysiology. JAMA Neurol. 2017 Jun 1;74(6):650-659. doi: 10.1001/jamaneurol.2016.5349. PubMed PMID: 28319241; PubMed Central PMCID: PMC5822210.

2: Eguchi J, Inomata Y, Saito K. The anxiolytic-like effect of MCI-225, a selective NA reuptake inhibitor with 5-HT3 receptor antagonism. Pharmacol Biochem Behav. 2001 Apr;68(4):677-83. PubMed PMID: 11526964.

3: Ishigooka J. [Serotonin-noradrenaline reuptake inhibitors(SNRIs)]. Nihon Rinsho. 2001 Aug;59(8):1523-9. Review. Japanese. PubMed PMID: 11519152.

4: Wu YL, Yoshida M, Emoto H, Ishii H, Koga K, Tanaka M. Effects of acute and chronic administration of MCI-225, a new selective noradrenaline reuptake inhibitor with 5-HT3 receptor blocking action, on extracellular noradrenaline levels in the hypothalamus of stressed rats. Jpn J Pharmacol. 2000 May;83(1):31-8. PubMed PMID: 10887938.

5: MCI 225. Drugs R D. 1999 Jul;2(1):51-2. PubMed PMID: 10610283.

6: Eguchi J, Inomata Y, Yuasa T, Egawa M, Saito K. Pharmacological profile of the novel antidepressant 4-(2-fluorophenyl)-6-methyl-2-(1-piperazinyl)thieno-[2,3-d]pyrimidine monohydrate hydrochloride. Arzneimittelforschung. 1997 Dec;47(12):1337-47. PubMed PMID: 9450161.

7: Eguchi J, Saitoh Y, Egawa M, Saito K, Kawamura H. MCI-225, a novel thienopyrimidine analog, enhances attentional eye tracking in midpontine pretrigeminal preparation. Pharmacol Biochem Behav. 1997 Feb;56(2):229-34. PubMed PMID: 9050079.

8: Eguchi J, Iwai K, Yuasa T, Egawa M, Komatsu T, Saito K. Effects of MCI-225 on memory and glucose utilization in basal forebrain-lesioned rats. Pharmacol Biochem Behav. 1995 Aug;51(4):935-9. PubMed PMID: 7675880.

9: Eguchi J, Yuasa T, Egawa M, Tobe A. Effects of a novel compound MCI-225 on impaired learning and memory in rats. Pharmacol Biochem Behav. 1994 Jun;48(2):345-9. PubMed PMID: 8090800.

10: Oishi R, Itoh Y, Adachi N, Saeki K. Effect of a new psychoactive compound, MCI-225, on brain monoamine metabolism in rats. Jpn J Pharmacol. 1993 Oct;63(2):261-4. PubMed PMID: 8283838.