WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H563618
CAS#: 149409-57-4
Description: NE100 HCl is a potent and selective sigma-1 receptor antagonist.
Hodoodo Cat#: H563618
Name: NE100 HCl
CAS#: 149409-57-4
Chemical Formula: C23H34ClNO2
Exact Mass: 391.23
Molecular Weight: 391.980
Elemental Analysis: C, 70.48; H, 8.74; Cl, 9.04; N, 3.57; O, 8.16
Synonym: NE100 Hydrochloride; NE-100 Hydrochloride; NE 100 Hydrochloride; NE100 HCl; NE-100 HCl; NE 100 HCl;
IUPAC/Chemical Name: N,N-Di-n-propyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl] ethylamine hydrochloride
InChi Key: ZHGMDXSHODHWHV-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H33NO2.ClH/c1-4-15-24(16-5-2)17-13-21-11-12-22(25-3)23(19-21)26-18-14-20-9-7-6-8-10-20;/h6-12,19H,4-5,13-18H2,1-3H3;1H
SMILES Code: COC1=CC=C(CCN(CCC)CCC)C=C1OCCC2=CC=CC=C2.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 391.98 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
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8: Sánchez-Blázquez P, Rodríguez-Muñoz M, Herrero-Labrador R, Burgueño J, Zamanillo D, Garzón J. The calcium-sensitive Sigma-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases. Int J Neuropsychopharmacol. 2014 Dec;17(12):1943-55. doi: 10.1017/S1461145714000029. Epub 2014 Jan 31. PubMed PMID: 24485144.
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10: Li L, Xu B, Zhu Y, Chen L, Sokabe M, Chen L. DHEA prevents Aβ25-35-impaired survival of newborn neurons in the dentate gyrus through a modulation of PI3K-Akt-mTOR signaling. Neuropharmacology. 2010 Sep-Oct;59(4-5):323-33. doi: 10.1016/j.neuropharm.2010.02.009. Epub 2010 Feb 16. PubMed PMID: 20167228.
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13: Li Z, Zhou R, Cui S, Xie G, Cai W, Sokabe M, Chen L. Dehydroepiandrosterone sulfate prevents ischemia-induced impairment of long-term potentiation in rat hippocampal CA1 by up-regulating tyrosine phosphorylation of NMDA receptor. Neuropharmacology. 2006 Oct;51(5):958-66. Epub 2006 Aug 8. PubMed PMID: 16895729.
14: Chen L, Dai XN, Sokabe M. Chronic administration of dehydroepiandrosterone sulfate (DHEAS) primes for facilitated induction of long-term potentiation via sigma 1 (sigma1) receptor: optical imaging study in rat hippocampal slices. Neuropharmacology. 2006 Mar;50(3):380-92. Epub 2005 Dec 20. PubMed PMID: 16364377.
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