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Nithiamide
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WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H592817

CAS#: 140-40-9

Description: Nithiamide is an Antibacterial drug.

Chemical Structure

Nithiamide

CAS# 140-40-9

Instruction

Theoretical Analysis

Hodoodo Cat#: H592817
Name: Nithiamide
CAS#: 140-40-9
Chemical Formula: C5H5N3O3S
Exact Mass: 187.01
Molecular Weight: 187.173
Elemental Analysis: C, 32.09; H, 2.69; N, 22.45; O, 25.64; S, 17.13

Price and Availability

Size	Price	Availability	Quantity
250mg	USD 340	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. Hodoodo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Nithiamide; NSC 45914; NSC-45914; NSC45914

IUPAC/Chemical Name: 2-Acetamido-5-nitrothiazole

InChi Key: UJRRDDHEMZLWFI-UHFFFAOYSA-N

InChi Code: InChI=1S/C5H5N3O3S/c1-3(9)7-5-6-2-4(12-5)8(10)11/h2H,1H3,(H,6,7,9)

SMILES Code: O=[N+](C1=CN=C(NC(C)=O)S1)[O-]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMF	3.0	16.03
	DMSO	10.0	53.43

Preparing Stock Solutions

The following data is based on the product molecular weight 187.17 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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1: Layton HW, Simkins KL, Eggert RG. Efficacy of nithiamide in preventing and treating swine dysentery in experimentally inoculated pigs. Am J Vet Res. 1977 May;38(5):627-31. PubMed PMID: 879561.

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6: Beliaeva OA. [The treatment of intra-abdominal abscess]. Klin Khir. 1998;(7):32-3. Russian. PubMed PMID: 9989085.

7: ISSHIKI T, MASHIKO Y, NINOMYA M. On the polarography of 2-acetamido-5-nitrothiazole. Pharm Bull. 1954 Sep;2(3):256-8. PubMed PMID: 13215049.

8: Tarasenko SV, Aleksashina IP, Agapov VS, Trukhina GM, Liapunov NA. [The use of nitatsid and gipozol'-N in the combined treatment of acute inflammatory diseases of the maxillofacial area]. Stomatologiia (Mosk). 2000;79(2):17-9. Russian. PubMed PMID: 10812984.

9: KURNATOWSKA A. [Essay with 2-acetylamino-5-nitrothiazole in the treatment of vaginal trichomoniasis]. Wiad Parazytol. 1958;4(5-6):557-9; English transl 559-60. Polish, Portuguese. PubMed PMID: 13604196.

10: CAVIER R, SAVEL J, RUCART G. [Pharmacological study of a trichomonacidal drug: 2-acetylamino-5-nitrothiazole]. Therapie. 1958;13(3):502-7. French. PubMed PMID: 13603384.

11: FEO LG, FETTER TR. Evaluation of tritheon (aminitrozole) in male trichomoniasis. J Urol. 1958 Jul;80(1):72-4. PubMed PMID: 13564590.

12: BARNES J, BOUTWOOD A, HAINES E, LEWINGTON W, LISTER E, HARAM BJ. Oral treatment of trichomonas vaginitis with aminitrozole. Br Med J. 1957 May 18;1(5028):1160-2. PubMed PMID: 13426568; PubMed Central PMCID: PMC1973492.

13: HORTON-SMITH C, LONG PL. The effect of 2-amino-5-nitrothiazole, 2-acetylamino-5-nitrothiazole and furazolidone on the growth in vitro of Histomonas meleagridis. Ann Trop Med Parasitol. 1957 Mar;51(1):117-20. PubMed PMID: 13425322.

14: WILLCOX RR. Novobiocin, spiramycin, and aminitrozole in the treatment of non-gonococcal urethritis. Br J Vener Dis. 1957 Sep;33(3):180-1. PubMed PMID: 13471970; PubMed Central PMCID: PMC1054155.

15: BERTOLI PE. [2-acetylamino-5-nitrothiazole therapy of trichomonas vaginitis]. Minerva Ginecol. 1957 Dec 31;9(24):1006-10. Italian. PubMed PMID: 13516698.

16: Kalinichenko NF, Osolodchenko TP, Liapunov NA, Starobinets ZG. [Antibacterial activity of some trichomonacidal agents]. Antibiot Khimioter. 1990 Nov;35(11):34-7. Russian. PubMed PMID: 2092637.

17: WILLCOX RR. Treatment of vaginal trichomoniasis with aminitrozole and trichomycin given orally. Gynaecologia. 1960;149(Suppl):122-7. PubMed PMID: 13844789.

18: Tsarev VN, Ushakov RV. [The immunomodulating therapy of odontogenic phlegmons with complexes of antibacterial preparations and water-soluble polymers for medical use]. Stomatologiia (Mosk). 1996;Spec No:88. Russian. PubMed PMID: 9281191.

19: DUNLOP EM, PHILIPP E, WATT JD. Oral treatment of trichomonal vaginitis with 2-acetylamino-5-nitrothiazole (tritheon). Br J Vener Dis. 1958 Mar;34(1):57. PubMed PMID: 13523204; PubMed Central PMCID: PMC1047166.

20: BRET J. [Treatment of trichomonas vaginitis with oral & local 2-acetylamino-5-nitrothiazole]. C R Soc Fr Gyncol. 1958 Apr;28(4):218-25. French. PubMed PMID: 13573806.

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