WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H563896
CAS#: NONE
Description: Nifrofam is a fluorescent probe for imaging α4β2* nAChRs.
Hodoodo Cat#: H563896
Name: Nifrofam
CAS#: NONE
Chemical Formula: C35H32N2O7
Exact Mass: 592.22
Molecular Weight: 592.650
Elemental Analysis: C, 70.93; H, 5.44; N, 4.73; O, 18.90
This product is not in stock, which may be available by custom synthesis.
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Synonym: Nifrofam
IUPAC/Chemical Name: (S)-2-(6-Hydroxy-3-oxo-3H-xanthen-9-yl)-4-((3-(3-(pyrrolidin-2-ylmethoxy)phenyl)propyl)carbamoyl)benzoic acid
InChi Key: HAAHPHQWRWQGBH-QHCPKHFHSA-N
InChi Code: InChI=1S/C35H32N2O7/c38-24-9-12-28-31(18-24)44-32-19-25(39)10-13-29(32)33(28)30-17-22(8-11-27(30)35(41)42)34(40)37-15-2-5-21-4-1-7-26(16-21)43-20-23-6-3-14-36-23/h1,4,7-13,16-19,23,36,38H,2-3,5-6,14-15,20H2,(H,37,40)(H,41,42)/t23-/m0/s1
SMILES Code: O=C(O)C1=CC=C(C(NCCCC2=CC=CC(OC[C@H]3NCCC3)=C2)=O)C=C1C4=C5C=CC(C=C5OC6=C4C=CC(O)=C6)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
More Info:
| Biological target: | |
| In vitro activity: | |
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The following data is based on the product molecular weight 592.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Samra GK, Intskirveli I, Govind AP, Liang C, Lazar R, Green WN, Metherate R, Mukherjee J. Development of fluorescence imaging probes for nicotinic acetylcholine α4β2(∗) receptors. Bioorg Med Chem Lett. 2017 Dec 17. pii: S0960-894X(17)31211-8. doi: 10.1016/j.bmcl.2017.12.036. [Epub ahead of print] PubMed PMID: 29277457; PubMed Central PMCID: PMC6004331.
