WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H564118
CAS#: 54490-26-5
Description: NSC745887 is an anticancer agent which traps DNA-topoisomerase cleavage and suppresses DcR3-associated signaling pathways. This causes apoptosis by the caspase-8/9-caspase-3-poly(ADP-ribose) polymerase cascade.
Hodoodo Cat#: H564118
Name: NSC745887
CAS#: 54490-26-5
Chemical Formula: C16H8N2O2
Exact Mass: 260.06
Molecular Weight: 260.250
Elemental Analysis: C, 73.84; H, 3.10; N, 10.76; O, 12.30
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Synonym: NSC-745887; NSC 745887; NSC745887
IUPAC/Chemical Name: Naphtho[2,3-f]quinoxaline-7,12-dione
InChi Key: DGLSEJAACVWJNU-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H8N2O2/c19-15-9-3-1-2-4-10(9)16(20)13-11(15)5-6-12-14(13)18-8-7-17-12/h1-8H
SMILES Code: O=C(C1=CC=C2N=CC=NC2=C1C3=O)C4=C3C=CC=C4
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 260.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Fann LY, Chen Y, Chu DC, Weng SJ, Chu HC, Wu ATH, Lee JF, Ali AAA, Chen TC, Huang HS, Ma KH. Identification and preclinical evaluation of the small molecule, NSC745887, for treating glioblastomas via suppressing DcR3-associated signaling pathways. Oncotarget. 2017 Dec 27;9(15):11922-11937. doi: 10.18632/oncotarget.23714. eCollection 2018 Feb 23. PubMed PMID: 29552282; PubMed Central PMCID: PMC5844718.
2: Chang YL, Lee HJ, Liu ST, Lin YS, Chen TC, Hsieh TY, Huang HS, Huang SM. Different roles of p53 in the regulation of DNA damage caused by 1,2-heteroannelated anthraquinones and doxorubicin. Int J Biochem Cell Biol. 2011 Dec;43(12):1720-8. doi: 10.1016/j.biocel.2011.08.006. Epub 2011 Aug 12. PubMed PMID: 21856437.