WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H564226
CAS#: 1565845-92-2
Description: 1E7-03 is an inhibitor of HIV-1 transcription, by targeting host Protein Phosphatase-1 (PP1).
Hodoodo Cat#: H564226
Name: 1E7-03
CAS#: 1565845-92-2
Chemical Formula: C28H29N3O6
Exact Mass: 503.21
Molecular Weight: 503.560
Elemental Analysis: C, 66.79; H, 5.81; N, 8.34; O, 19.06
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Synonym: 1E703; 1E7 03; 1E7-03
IUPAC/Chemical Name: (E)-3-(3,4-Dimethoxy-benzylidene)-2,3-dihydro-1H-cyclopenta[b]quinoline-9-carboxylic acid 2-(3-ethyl-ureido)-1-methyl-2-oxo-ethyl ester
InChi Key: PHJQCMBFMOQNFF-NBVRZTHBSA-N
InChi Code: InChI=1S/C28H29N3O6/c1-5-29-28(34)31-26(32)16(2)37-27(33)24-19-8-6-7-9-21(19)30-25-18(11-12-20(24)25)14-17-10-13-22(35-3)23(15-17)36-4/h6-10,13-16H,5,11-12H2,1-4H3,(H2,29,31,32,34)/b18-14+
SMILES Code: O=C(C1=C(CC/C2=C\C3=CC=C(OC)C(OC)=C3)C2=NC4=CC=CC=C14)OC(C)C(NC(NCC)=O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 503.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Lin X, Kumari N, DeMarino C, Kont YS, Ammosova T, Kulkarni A, Jerebtsova M, Vazquez-Meves G, Ivanov A, Dmytro K, Üren A, Kashanchi F, Nekhai S. Inhibition of HIV-1 infection in humanized mice and metabolic stability of protein phosphatase-1-targeting small molecule 1E7-03. Oncotarget. 2017 Aug 7;8(44):76749-76769. doi: 10.18632/oncotarget.19999. eCollection 2017 Sep 29. PubMed PMID: 29100346; PubMed Central PMCID: PMC5652740.
2: Ammosova T, Platonov M, Ivanov A, Kont YS, Kumari N, Kehn-Hall K, Jerebtsova M, Kulkarni AA, Uren A, Kovalskyy D, Nekhai S. 1E7-03, a low MW compound targeting host protein phosphatase-1, inhibits HIV-1 transcription. Br J Pharmacol. 2014 Nov;171(22):5059-75. doi: 10.1111/bph.12863. PubMed PMID: 25073485; PubMed Central PMCID: PMC4253456.