WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H528047
CAS#: 4697-83-0
Description: 17-Oxolupanine is a bioactive chemical.
Hodoodo Cat#: H528047
Name: 17-Oxolupanine
CAS#: 4697-83-0
Chemical Formula: C15H22N2O2
Exact Mass: 262.17
Molecular Weight: 262.353
Elemental Analysis: C, 68.67; H, 8.45; N, 10.68; O, 12.20
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Synonym: 17-Oxolupanine
IUPAC/Chemical Name: 7,14-Methano-4H,6H-dipyrido(1,2-a:1',2'-e)(1,5)diazocine-4,13(14H)-dione, decahydro-, (7S-(7alpha,7abeta,14alpha,14aalpha))-
InChi Key: HBYSMHYHSFSCED-QNWHQSFQSA-N
InChi Code: InChI=1S/C15H22N2O2/c18-14-6-3-5-13-11-8-10(9-17(13)14)12-4-1-2-7-16(12)15(11)19/h10-13H,1-9H2/t10-,11+,12-,13+/m0/s1
SMILES Code: O=C1CCC[C@@]([C@@]2([H])C3)([H])N1C[C@@]3([H])[C@@](CCCC4)([H])N4C2=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 262.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Parmaki S, Vyrides I, Vasquez MI, Hartman V, Zacharia I, Hadjiadamou I, Barbeitos CBM, Ferreira FC, Afonso CAM, Drouza C, Koutinas M. Bioconversion of alkaloids to high-value chemicals: Comparative analysis of newly isolated lupanine degrading strains. Chemosphere. 2018 Feb;193:50-59. doi: 10.1016/j.chemosphere.2017.10.165. Epub 2017 Oct 30. PubMed PMID: 29126065.
2: Adler LS, Wink M. Transfer of quinolizidine alkaloids from hosts to hemiparasites in two Castilleja-Lupinus associations: analysis of floral and vegetative tissues. Biochem Syst Ecol. 2001 Jun;29(6):551-561. PubMed PMID: 11336806.
3: Wink M, Witte L, Hartmann T, Theuring C, Volz V. Accumulation of quinolizidine alkaloids in plants and cell suspension cultures: genera lupinus, cytisus, baptisia, genista, laburnum, and sophora. Planta Med. 1983 Aug;48(8):253-7. PubMed PMID: 17404991.
4: Wink M, Witte L, Hartmann T. Quinolizidine alkaloid composition of plants and of photomixotrophic cell suspension cultures of Sarothamnus scoparius and Orobanche rapum-genistae. Planta Med. 1981 Dec;43(4):342-52. PubMed PMID: 17402058.
5: Keeler RF, Gross R. The total alkaloid and anagyrine contents of some bitter and sweet selections of lupin species used as food. J Environ Pathol Toxicol. 1980 Jun-Jul;3(5-6):333-40. PubMed PMID: 7441088.
6: Mazur M, Polakowski P, Szadowska A. [Pharmacologic studies on 17-oxolupanine, lupanine aminooxide and 17-hydroxylupanine]. Acta Physiol Pol. 1966 Mar-Apr;17(2):311-20. Polish. PubMed PMID: 5945524.