WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H564299
CAS#: NONE
Description: NC2213 is an inhibitor of methionine aminopeptidase 2 (MetAP2).
Hodoodo Cat#: H564299
Name: NC2213
CAS#: NONE
Chemical Formula: C24H27N3O11S2
Exact Mass: 0.00
Molecular Weight: 597.610
Elemental Analysis: C, 48.24; H, 4.55; N, 7.03; O, 29.45; S, 10.73
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Synonym: NC-2213; NC 2213; NC2213
IUPAC/Chemical Name: 2-((3-(3,5-bis((E)-4-nitrobenzylidene)-4-oxopiperidin-1-yl)-3-oxopropyl)thio)ethane-1-sulfonic acid dihydrate
InChi Key: ABOORZPMWQNZAY-HPKCLRQXSA-N
InChi Code: InChI=1S/C24H23N3O9S2.2H2O/c28-23(9-10-37-11-12-38(34,35)36)25-15-19(13-17-1-5-21(6-2-17)26(30)31)24(29)20(16-25)14-18-3-7-22(8-4-18)27(32)33;;/h1-8,13-14H,9-12,15-16H2,(H,34,35,36);2*1H2/b19-13+,20-14+;;
SMILES Code: O=S(CCSCCC(N1C/C(C(/C(C1)=C/C2=CC=C([N+]([O-])=O)C=C2)=O)=C\C3=CC=C([N+]([O-])=O)C=C3)=O)(O)=O.[H]O[H].[H]O[H]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 597.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Selvakumar P, Lakshmikuttyamma A, Das U, Pati HN, Dimmock JR, Sharma RK. NC2213: a novel methionine aminopeptidase 2 inhibitor in human colon cancer HT29 cells. Mol Cancer. 2009 Aug 24;8:65. doi: 10.1186/1476-4598-8-65. PubMed PMID: 19703310; PubMed Central PMCID: PMC2740849.