WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H564310
CAS#: 19891-51-1
Description: Nagilactone B is a unique selective LXR regulator which suppresses atherosclerosis in apoE-deficient mice via promotion of cholesterol efflux in macrophages.
Hodoodo Cat#: H564310
Name: Nagilactone B
CAS#: 19891-51-1
Chemical Formula: C19H24O7
Exact Mass: 364.15
Molecular Weight: 364.394
Elemental Analysis: C, 62.63; H, 6.64; O, 30.73
Synonym: Nagilactone B
IUPAC/Chemical Name: (1S,2R,3aS,5aS,6R,10bS,10cR)-1,2,6-Trihydroxy-3a,10b-dimethyl-7-(1-methylethyl)-1,2,3,3a,5a,6,10b,10c-octahydro-4H,9H-[2]benzofuro[7,1-fg]isochromene-4,9-dione
InChi Key: AEGWYWSJGKOLGB-ZLNDBNLZSA-N
InChi Code: InChI=1S/C19H24O7/c1-7(2)13-11-8(5-10(21)25-13)19(4)15-14(12(11)22)26-17(24)18(15,3)6-9(20)16(19)23/h5,7,9,12,14-16,20,22-23H,6H2,1-4H3/t9-,12-,14-,15+,16-,18+,19-/m1/s1
SMILES Code: O=C(O1)[C@@]2(C)C[C@@H](O)[C@@H](O)[C@]3(C)C4=CC(OC(C(C)C)=C4[C@@H](O)[C@]1([H])[C@]32[H])=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 364.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Gui Y, Yao S, Yan H, Hu L, Yu C, Gao F, Xi C, Li H, Ye Y, Wang Y. A novel small molecule liver X receptor transcriptional regulator, nagilactone B, suppresses atherosclerosis in apoE-deficient mice. Cardiovasc Res. 2016 Oct;112(1):502-14. doi: 10.1093/cvr/cvw183. Epub 2016 Jul 26. PubMed PMID: 27460841.