WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H564316
CAS#: NONE
Description: NUC041 is a prodrug of NUC013, which is a novel DNA methytransferase inhibitor.
Hodoodo Cat#: H564316
Name: NUC041
CAS#: NONE
Chemical Formula: C14H26F2N4O4Si2
Exact Mass: 408.15
Molecular Weight: 408.550
Elemental Analysis: C, 41.16; H, 6.41; F, 9.30; N, 13.71; O, 15.66; Si, 13.75
This product is not in stock, which may be available by custom synthesis.
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Synonym: NUC-041; NUC 041; NUC041
IUPAC/Chemical Name: 3',5'-Di-trimethylsilyl-2',2'-difluoro-5-azadeoxycytidine
InChi Key: YILNROOJILNAPQ-VTWNZUCVSA-N
InChi Code: InChI=1S/C14H26F2N4O4Si2/c1-25(2,3)9(21)8-14(23,26(4,5)6)13(15,16)10(24-8)20-7-18-11(17)19-12(20)22/h7-10,21,23H,1-6H3,(H2,17,19,22)/t8-,9?,10-,14+/m1/s1
SMILES Code: OC([Si](C)(C)C)[C@@H]1[C@@](C(F)(F)[C@H](N2C(N=C(N=C2)N)=O)O1)([Si](C)(C)C)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 408.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Daifuku R, Grimes S, Stackhouse M. NUC041, a Prodrug of the DNA Methytransferase Inhibitor 5-aza-2',2'-Difluorodeoxycytidine (NUC013), Leads to Tumor Regression in a Model of Non-Small Cell Lung Cancer. Pharmaceuticals (Basel). 2018 Apr 23;11(2). pii: E36. doi: 10.3390/ph11020036. PubMed PMID: 29690576; PubMed Central PMCID: PMC6027359.