WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H573161
CAS#: 2139-47-1
Description: Nifenazone is a drug used as an analgesic for a number of rheumatic conditions.
Hodoodo Cat#: H573161
Name: Nifenazone
CAS#: 2139-47-1
Chemical Formula: C17H16N4O2
Exact Mass: 308.13
Molecular Weight: 308.341
Elemental Analysis: C, 66.22; H, 5.23; N, 18.17; O, 10.38
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Synonym: N-Antipyrinylnicotinamide, Niapyrin, Nicazane, Nicodon, Nicodone, Nicofesone, Nicophesone, Nicophezon, Nicopyron, Nicoreumal, Nicoron, Nicotazone, Nifenazone
IUPAC/Chemical Name: Nicotinamide, N-(2,3-dimethyl-5-oxo-1-phenyl-3-pyrazolin-4-yl)-
InChi Key: BRZANEXCSZCZCI-UHFFFAOYSA-N
InChi Code: 1S/C17H16N4O2/c1-12-15(19-16(22)13-7-6-10-18-11-13)17(23)21(20(12)2)14-8-4-3-5-9-14/h3-11H,1-2H3,(H,19,22)
SMILES Code: Cc1c(c(=O)n(n1C)c2ccccc2)NC(=O)c3cccnc3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 308.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Bani-Yaseen AD, Al-Balawi M. The solvatochromic, spectral, and geometrical properties of nifenazone: a DFT/TD-DFT and experimental study. Phys Chem Chem Phys. 2014 Aug 7;16(29):15519-26. doi: 10.1039/c4cp01679c. Epub 2014 Jun 23. PubMed PMID: 24954054.
2: Beyer KH, Friese J. [Nifenazone, biotransformation in humans]. Arch Pharm (Weinheim). 1985 Sep;318(9):855-63. German. PubMed PMID: 2935118.
3: Gola A, Galazka Z, Szczeklik A. Evaluation of liver function during administration of nifenazone in rheumatic disease on the basis of serum protein studies and enzyme tests. Mater Med Pol. 1972 Apr-Jun;4(2):66-70. PubMed PMID: 4270064.
4: HART FD, BOARDMAN PL. TRIAL OF NIFENAZONE ("THYLIN"). Br Med J. 1964 Jun 13;1(5397):1553-4. PubMed PMID: 14133613; PubMed Central PMCID: PMC1814611.