WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H584688
CAS#: 59593-16-7
Description: Neothramycin A is a pyrrol[1,4]benzodiazepine antibiotic.
Hodoodo Cat#: H584688
Name: Neothramycin A
CAS#: 59593-16-7
Chemical Formula: C13H14N2O4
Exact Mass: 262.10
Molecular Weight: 262.265
Elemental Analysis: C, 59.54; H, 5.38; N, 10.68; O, 24.40
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Synonym: Neothramycin A; Antibiotic MC-916-A; MC-916-A
IUPAC/Chemical Name: 5H-Pyrrolo(2,1-c)(1,4)benzodiazepin-5-one, 1,2,3,11a-tetrahydro-3,8-dihydroxy-7-methoxy-, (3S-trans)-
InChi Key: FXMOIYLVKOALHC-MADCSZMMSA-N
InChi Code: InChI=1S/C13H14N2O4/c1-19-11-4-8-9(5-10(11)16)14-6-7-2-3-12(17)15(7)13(8)18/h4-7,12,16-17H,2-3H2,1H3/t7-,12-/m0/s1
SMILES Code: O=C1N2[C@](CC[C@@H]2O)([H])C=NC3=CC(O)=C(OC)C=C13
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 262.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Rao SN, Remers WA. All atom molecular mechanics simulations on covalent complexes of anthramycin and neothramycin with deoxydecanucleotides. J Med Chem. 1990 Jun;33(6):1701-7. PubMed PMID: 2342065.
2: Remers WA, Mabilia M, Hopfinger AJ. Conformations of complexes between pyrrolo[1,4]benzodiazepines and DNA segments. J Med Chem. 1986 Dec;29(12):2492-503. PubMed PMID: 3783609.
3: Petrusek RL, Anderson GL, Garner TF, Fannin QL, Kaplan DJ, Zimmer SG, Hurley LH. Pyrrol[1,4]benzodiazepine antibiotics. Proposed structures and characteristics of the in vitro deoxyribonucleic acid adducts of anthramycin, tomaymycin, sibiromycin, and neothramycins A and B. Biochemistry. 1981 Mar 3;20(5):1111-9. PubMed PMID: 6261786.
4: Morris SJ, Thurston DE, Nevell TG. Evaluation of the electrophilicity of DNA-binding pyrrolo[2,1-c][1,4]benzodiazepines by HPLC. J Antibiot (Tokyo). 1990 Oct;43(10):1286-92. PubMed PMID: 2258327.