WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H564552
CAS#: 11023-94-2
Description: Nothofagin is a natural anti-oxidant which inhibits endothelial protein C receptor (EPCR) shedding. Nothofagin shows diuretic, natriuretic, and potassium-sparing effects associated with prostanoids generation and muscarinic receptor activation.
Hodoodo Cat#: H564552
Name: Nothofagin
CAS#: 11023-94-2
Chemical Formula: C21H24O10
Exact Mass: 436.14
Molecular Weight: 436.413
Elemental Analysis: C, 57.80; H, 5.54; O, 36.66
Synonym: Nothofagin
IUPAC/Chemical Name: 3-(4-Hydroxyphenyl)-1-[2,4,6-trihydroxy-3-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]phenyl]propan-1-one
InChi Key: VZBPTZZTCBNBOZ-VJXVFPJBSA-N
InChi Code: InChI=1S/C21H24O10/c22-8-14-17(27)19(29)20(30)21(31-14)16-13(26)7-12(25)15(18(16)28)11(24)6-3-9-1-4-10(23)5-2-9/h1-2,4-5,7,14,17,19-23,25-30H,3,6,8H2/t14-,17-,19+,20-,21+/m1/s1
SMILES Code: O=C(C1=C(O)C=C(O)C([C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)=C1O)CCC3=CC=C(O)C=C3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 436.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Kang BC, Kim MJ, Lee S, Choi YA, Park PH, Shin TY, Kwon TK, Khang D, Kim SH. Nothofagin suppresses mast cell-mediated allergic inflammation. Chem Biol Interact. 2018 Oct 28;298:1-7. doi: 10.1016/j.cbi.2018.10.025. [Epub ahead of print] PubMed PMID: 30392763.
2: Yang S, Lee C, Lee BS, Park EK, Kim KM, Bae JS. Renal protective effects of aspalathin and nothofagin from rooibos (Aspalathus linearis) in a mouse model of sepsis. Pharmacol Rep. 2018 Jul 27;70(6):1195-1201. doi: 10.1016/j.pharep.2018.07.004. [Epub ahead of print] PubMed PMID: 30340097.
3: de Almeida CLB, Cechinel-Filho V, Boeing T, Mariano LNB, Silva LMD, Andrade SF, de Souza P. Prolonged diuretic and saluretic effect of nothofagin isolated from Leandra dasytricha (A. Gray) Cogn. leaves in normotensive and hypertensive rats: Role of antioxidant system and renal protection. Chem Biol Interact. 2018 Jan 5;279:227-233. doi: 10.1016/j.cbi.2017.11.021. Epub 2017 Dec 1. PubMed PMID: 29198636.
4: Schmölzer K, Lemmerer M, Nidetzky B. Glycosyltransferase cascades made fit for chemical production: Integrated biocatalytic process for the natural polyphenol C-glucoside nothofagin. Biotechnol Bioeng. 2018 Mar;115(3):545-556. doi: 10.1002/bit.26491. Epub 2017 Nov 27. PubMed PMID: 29131308.
5: de Almeida CL, Boeing T, Somensi LB, Steimbach VM, da Silva LM, Andrade SF, Delle Monache F, Cechinel-Filho V, de Souza P. Diuretic, natriuretic and potassium-sparing effect of nothofagin isolated from Leandra dasytricha (A. Gray) Cogn. leaves in normotensive and hypertensive rats. Chem Biol Interact. 2017 Apr 25;268:103-110. doi: 10.1016/j.cbi.2017.03.004. Epub 2017 Mar 8. PubMed PMID: 28284659.
6: Lee W, Kim KM, Bae JS. Ameliorative Effect of Aspalathin and Nothofagin from Rooibos (Aspalathus linearis) on HMGB1-Induced Septic Responses In Vitro and In Vivo. Am J Chin Med. 2015;43(5):991-1012. doi: 10.1142/S0192415X15500573. Epub 2015 Jul 30. PubMed PMID: 26224030.
7: Lee W, Bae JS. Anti-inflammatory Effects of Aspalathin and Nothofagin from Rooibos (Aspalathus linearis) In Vitro and In Vivo. Inflammation. 2015 Aug;38(4):1502-16. doi: 10.1007/s10753-015-0125-1. PubMed PMID: 25655391.
8: de Beer D, Malherbe CJ, Beelders T, Willenburg EL, Brand DJ, Joubert E. Isolation of aspalathin and nothofagin from rooibos (Aspalathus linearis) using high-performance countercurrent chromatography: sample loading and compound stability considerations. J Chromatogr A. 2015 Feb 13;1381:29-36. doi: 10.1016/j.chroma.2014.12.078. Epub 2015 Jan 7. PubMed PMID: 25614190.
9: Kwak S, Han MS, Bae JS. Aspalathin and nothofagin from rooibos (Aspalathus linearis) inhibit endothelial protein C receptor shedding in vitro and in vivo. Fitoterapia. 2015 Jan;100:179-86. doi: 10.1016/j.fitote.2014.12.002. Epub 2014 Dec 12. PubMed PMID: 25510322.
10: Ku SK, Kwak S, Kim Y, Bae JS. Aspalathin and Nothofagin from Rooibos (Aspalathus linearis) inhibits high glucose-induced inflammation in vitro and in vivo. Inflammation. 2015 Feb;38(1):445-55. doi: 10.1007/s10753-014-0049-1. PubMed PMID: 25338943.
