17-Hydroxycativic acid

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H564737

CAS#: NONE

Description: 17-Hydroxycativic acid is an acetylcholinesterase (AChE) inhibitor.

Chemical Structure

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17-Hydroxycativic acid
CAS# NONE
Instruction

Theoretical Analysis

Hodoodo Cat#: H564737
Name: 17-Hydroxycativic acid
CAS#: NONE
Chemical Formula: C20H34O3
Exact Mass: 322.25
Molecular Weight: 322.490
Elemental Analysis: C, 74.49; H, 10.63; O, 14.88

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: 17 Hydroxycativic acid; 17Hydroxycativic acid; 17-Hydroxycativic acid

IUPAC/Chemical Name: (3S)-5-[(1R,4aS,8aS)-2-(Hydroxymethyl)-5,5,8a-trimethyl-1,4,4a,6,7,8-hexahydronaphthalen-1-yl]-3-methylpentanoic acid

InChi Key: HSPKTTDVALANJO-JWWIWJDOSA-N

InChi Code: InChI=1S/C20H34O3/c1-14(12-18(22)23)6-8-16-15(13-21)7-9-17-19(2,3)10-5-11-20(16,17)4/h7,14,16-17,21H,5-6,8-13H2,1-4H3,(H,22,23)/t14-,16-,17-,20+/m0/s1

SMILES Code: O=C(O)C[C@@H](C)CC[C@H]1C(CO)=CC[C@@]2([H])C(C)(C)CCC[C@]12C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 322.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Cavallaro V, Řezníčková E, Jorda R, Alza NP, Murray AP, Kryštof V. Semisynthetic Esters of 17-Hydroxycativic Acid with in Vitro Cytotoxic Activity against Leukemia Cell Lines. Biol Pharm Bull. 2017;40(11):1923-1928. doi: 10.1248/bpb.b17-00477. PubMed PMID: 29093339.

2: Alza NP, Murray AP, Salvador GA. Cativic acid-caffeic acid hybrid exerts cytotoxic effects and induces apoptotic death in human neuroblastoma cells. Naunyn Schmiedebergs Arch Pharmacol. 2017 Dec;390(12):1229-1238. doi: 10.1007/s00210-017-1421-0. Epub 2017 Sep 5. PubMed PMID: 28875231.

3: Alza NP, Richmond V, Baier CJ, Freire E, Baggio R, Murray AP. Synthesis and cholinesterase inhibition of cativic acid derivatives. Bioorg Med Chem. 2014 Aug 1;22(15):3838-49. doi: 10.1016/j.bmc.2014.06.030. Epub 2014 Jun 26. PubMed PMID: 25017625.