WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H564794
CAS#: NONE
Description: N-n-Butyl haloperidol iodide is an inhibitor of autophagy which protects cardiomyocytes against hypoxia and reoxygenation injury.
Hodoodo Cat#: H564794
Name: N-n-Butyl Haloperidol Iodide
CAS#: NONE
Chemical Formula: C25H32ClFINO2
Exact Mass: 0.00
Molecular Weight: 559.890
Elemental Analysis: C, 53.63; H, 5.76; Cl, 6.33; F, 3.39; I, 22.67; N, 2.50; O, 5.72
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Synonym: N-n-Butyl haloperidol iodide
IUPAC/Chemical Name: 1-Butyl-4-(4-chloro-phenyl)-1-[4-(4-fluoro-phenyl)-4-oxo-butyl]-4-hydroxy-piperidinium iodide
InChi Key: JZOLZUFLPKVJDH-UHFFFAOYSA-M
InChi Code: InChI=1S/C25H32ClFNO2.HI/c1-2-3-16-28(17-4-5-24(29)20-6-12-23(27)13-7-20)18-14-25(30,15-19-28)21-8-10-22(26)11-9-21;/h6-13,30H,2-5,14-19H2,1H3;1H/q+1;/p-1
SMILES Code: OC1(C2=CC=C(Cl)C=C2)CC[N+](CCCC(C3=CC=C(F)C=C3)=O)(CCCC)CC1.[I-]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 559.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Lu B, Wang B, Zhong S, Zhang Y, Gao F, Chen Y, Zheng F, Shi G. N-n-butyl haloperidol iodide ameliorates hypoxia/reoxygenation injury through modulating the LKB1/AMPK/ROS pathway in cardiac microvascular endothelial cells. Oncotarget. 2016 Jun 7;7(23):34800-10. doi: 10.18632/oncotarget.9186. PubMed PMID: 27166184; PubMed Central PMCID: PMC5085190.
2: Wang B, Zhong S, Zheng F, Zhang Y, Gao F, Chen Y, Lu B, Xu H, Shi G. N-n-butyl haloperidol iodide protects cardiomyocytes against hypoxia/reoxygenation injury by inhibiting autophagy. Oncotarget. 2015 Sep 22;6(28):24709-21. doi: 10.18632/oncotarget.5077. PubMed PMID: 26359352; PubMed Central PMCID: PMC4694790.
3: Zhang Y, Liao H, Zhong S, Gao F, Chen Y, Huang Z, Lu S, Sun T, Wang B, Li W, Xu H, Zheng F, Shi G. Effect of N-n-butyl haloperidol iodide on ROS/JNK/Egr-1 signaling in H9c2 cells after hypoxia/reoxygenation. Sci Rep. 2015 Jul 2;5:11809. doi: 10.1038/srep11809. PubMed PMID: 26134032; PubMed Central PMCID: PMC4488875.
4: Huang YP, Gao FF, Wang B, Zheng FC, Zhang YM, Chen YC, Huang ZQ, Zheng YS, Zhong SP, Shi GG. N-n-butyl haloperidol iodide inhibits H2O2-induced Na+/Ca2+-exchanger activation via the Na+/H+ exchanger in rat ventricular myocytes. Drug Des Devel Ther. 2014 Sep 9;8:1257-67. doi: 10.2147/DDDT.S63163. eCollection 2014. PubMed PMID: 25246767; PubMed Central PMCID: PMC4166912.
5: Zhang Y, Chen G, Zhong S, Zheng F, Gao F, Chen Y, Huang Z, Cai W, Li W, Liu X, Zheng Y, Xu H, Shi G. N-n-butyl haloperidol iodide ameliorates cardiomyocytes hypoxia/reoxygenation injury by extracellular calcium-dependent and -independent mechanisms. Oxid Med Cell Longev. 2013;2013:912310. doi: 10.1155/2013/912310. Epub 2013 Nov 12. PubMed PMID: 24392181; PubMed Central PMCID: PMC3857550.