PF-06297470
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    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H555416

CAS#: 1539296-45-1

Description: PF-06297470 is a potent negative allosteric modulator of the Metabotropic Glutamate Receptor 5 (mGluR5). PF-06297470 binds to mGluR5 with a Ki of 0.9 nM.

Chemical Structure

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PF-06297470
CAS# 1539296-45-1
Instruction

Theoretical Analysis

Hodoodo Cat#: H555416
Name: PF-06297470
CAS#: 1539296-45-1
Chemical Formula: C18H16N6O
Exact Mass: 332.14
Molecular Weight: 332.367
Elemental Analysis: C, 65.05; H, 4.85; N, 25.29; O, 4.81

Price and Availability

Size Price Availability Quantity
5mg USD 285 2 Weeks
25mg USD 850 2 Weeks
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Synonym: PF-06297470; PF 06297470; PF06297470; PF-6297470; PF 6297470; PF6297470;

IUPAC/Chemical Name: 1-Methyl-3-(4-methyl-3-pyridinyl)-6-(2-pyridinylmethoxy)-1H-pyrazolo[3,4-b]pyrazine

InChi Key: RDLSKDOSNKLEAQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H16N6O/c1-12-6-8-19-9-14(12)16-17-18(24(2)23-16)22-15(10-21-17)25-11-13-5-3-4-7-20-13/h3-10H,11H2,1-2H3

SMILES Code: CC1=C(C2=NN(C)C3=NC(OCC4=NC=CC=C4)=CN=C32)C=NC=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 332.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Palanisamy GS, Marcek JM, Cappon GD, Whritenour J, Shaffer CL, Brady JT, Houle
C. Drug-induced Skin Lesions in Cynomolgus Macaques Treated with Metabotropic
Glutamate Receptor 5 (mGluR5) Negative Allosteric Modulators. Toxicol Pathol.
2015 Oct;43(7):995-1003. doi: 10.1177/0192623315588114. Epub 2015 Jun 9. PubMed
PMID: 26059827.