WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H564844
CAS#: 897613-29-5
Description: S1QEL is a suppressor of mitochondrial respiratory complex I site IQ electron leak which suppresses superoxide and/or H2O2 production without altering oxidative phosphorylation.
Hodoodo Cat#: H564844
Name: S1QEL
CAS#: 897613-29-5
Chemical Formula: C23H24N4O3S
Exact Mass: 436.16
Molecular Weight: 436.530
Elemental Analysis: C, 63.28; H, 5.54; N, 12.83; O, 11.00; S, 7.34
Synonym: S1-QEL; S1 QEL; S1QEL; S-1QEL; S 1QEL; S1QEL1.1
IUPAC/Chemical Name: N1-(3-Acetamidophenyl)-N2-(2-(4-methyl-2-(p-tolyl)thiazol-5-yl)ethyl)oxalamide
InChi Key: BFNBJUBXXJKBFN-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H24N4O3S/c1-14-7-9-17(10-8-14)23-25-15(2)20(31-23)11-12-24-21(29)22(30)27-19-6-4-5-18(13-19)26-16(3)28/h4-10,13H,11-12H2,1-3H3,(H,24,29)(H,26,28)(H,27,30)
SMILES Code: O=C(NC1=CC=CC(NC(C)=O)=C1)C(NCCC2=C(C)N=C(C3=CC=C(C)C=C3)S2)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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In vitro activity: | |
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The following data is based on the product molecular weight 436.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Wong HS, Benoit B, Brand MD. Mitochondrial and cytosolic sources of hydrogen peroxide in resting C2C12 myoblasts. Free Radic Biol Med. 2019 Jan;130:140-150. doi: 10.1016/j.freeradbiomed.2018.10.448. Epub 2018 Oct 31. PubMed PMID: 30389498.