WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H531362
CAS#: 1539296-46-2
Description: PF-06422913 is an orally active, potent and selective metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator.
Hodoodo Cat#: H531362
Name: PF-06422913
CAS#: 1539296-46-2
Chemical Formula: C18H13F3N6O
Exact Mass: 386.11
Molecular Weight: 386.338
Elemental Analysis: C, 55.96; H, 3.39; F, 14.75; N, 21.75; O, 4.14
Synonym: PF-06422913
IUPAC/Chemical Name: 1-Methyl-6-(2-pyridinylmethoxy)-3-[4-(trifluoromethyl)-3-pyridinyl]-1H-pyrazolo[3,4-b]prazine
InChi Key: UHUFBNVEMLJTKS-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H13F3N6O/c1-27-17-16(15(26-27)12-8-22-7-5-13(12)18(19,20)21)24-9-14(25-17)28-10-11-4-2-3-6-23-11/h2-9H,10H2,1H3
SMILES Code: FC(C1=C(C2=NN(C)C3=NC(OCC4=NC=CC=C4)=CN=C32)C=NC=C1)(F)F
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 386.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
