WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H584810
CAS#: 26351-71-3
Description: NK 2 is a membrane-acting antimicrobial peptide.
Hodoodo Cat#: H584810
Name: NK 2
CAS#: 26351-71-3
Chemical Formula: C15H11Cl2NO6
Exact Mass: 371.00
Molecular Weight: 372.154
Elemental Analysis: C, 48.41; H, 2.98; Cl, 19.05; N, 3.76; O, 25.79
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Synonym: NK 2; NK-2; NK2
IUPAC/Chemical Name: (2,4-Dichlorophenoxy)acetic acid, (4-hydroxy-3-nitrophenyl)methyl ester
InChi Key: YHLOHJDPOCXQQD-UHFFFAOYSA-N
InChi Code: InChI=1S/C15H11Cl2NO6/c16-10-2-4-14(11(17)6-10)23-8-15(20)24-7-9-1-3-13(19)12(5-9)18(21)22/h1-6,19H,7-8H2
SMILES Code: O=C(OCC1=CC=C(O)C([N+]([O-])=O)=C1)COC2=CC=C(Cl)C=C2Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 372.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Andrä J, Koch MH, Bartels R, Brandenburg K. Biophysical characterization of endotoxin inactivation by NK-2, an antimicrobial peptide derived from mammalian NK-lysin. Antimicrob Agents Chemother. 2004 May;48(5):1593-9. PubMed PMID: 15105110; PubMed Central PMCID: PMC400566.
2: Hsu CC, Lin RL, Lin YS, Lee LY. Bronchoconstriction induced by increasing airway temperature in ovalbumin-sensitized rats: role of tachykinins. J Appl Physiol (1985). 2013 Sep 1;115(5):688-96. doi: 10.1152/japplphysiol.00491.2013. Epub 2013 Jul 11. PubMed PMID: 23845978; PubMed Central PMCID: PMC3763070.
3: Dragan AI, Li Z, Makeyeva EN, Milgotina EI, Liu Y, Crane-Robinson C, Privalov PL. Forces driving the binding of homeodomains to DNA. Biochemistry. 2006 Jan 10;45(1):141-51. PubMed PMID: 16388589.
4: Jena P, Mishra B, Leippe M, Hasilik A, Griffiths G, Sonawane A. Membrane-active antimicrobial peptides and human placental lysosomal extracts are highly active against mycobacteria. Peptides. 2011 May;32(5):881-7. doi: 10.1016/j.peptides.2011.03.002. Epub 2011 Mar 17. PubMed PMID: 21396418.