WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H584842
CAS#: 84233-61-4
Description: Nesosteine is a mucoregulatory agent.
Hodoodo Cat#: H584842
Name: Nesosteine
CAS#: 84233-61-4
Chemical Formula: C11H11NO3S
Exact Mass: 237.05
Molecular Weight: 237.273
Elemental Analysis: C, 55.68; H, 4.67; N, 5.90; O, 20.23; S, 13.51
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Synonym: Nesosteine
IUPAC/Chemical Name: o-(3-Thiazolidinylcarbonyl)benzoic acid
InChi Key: XVAYJUBRRZOANH-UHFFFAOYSA-N
InChi Code: InChI=1S/C11H11NO3S/c13-10(12-5-6-16-7-12)8-3-1-2-4-9(8)11(14)15/h1-4H,5-7H2,(H,14,15)
SMILES Code: O=C(O)C1=CC=CC=C1C(N2CSCC2)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 237.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Franchi-Micheli S, Luzzi S, Ciuffi M, Gori A, Castiglioni C, Zilletti L. Effects of nesosteine on Herxheimer microshock in guinea-pigs. Agents Actions. 1987 Apr;20(3-4):327-9. PubMed PMID: 2440286.
2: Braga PC, Bossi R, Castiglioni CL, Romandini S, Allegra L. Preliminary data on the action of nesosteine, a mucomodifying drug, on mucociliary transport. J Int Med Res. 1987 Jan-Feb;15(1):57-61. PubMed PMID: 3817282.
3: Scuri R, Mondani P, Frova C, Fantini L. Nesosteine: a new mucoregulatory agent. Drugs Exp Clin Res. 1986;12(8):663-70. PubMed PMID: 3757762.
4: Braga PC, Beghi G, Castelli C, Grasselli G, Ornaghi A, Rampoldi C, Zheng Y, Allegra L. Rheological profile of nesosteine: a new mucoactive agent. Int J Clin Pharmacol Res. 1989;9(1):77-83. PubMed PMID: 2707929.
5: Gatto PG, Gramolini C, Valenti S. [Effectiveness and tolerance of a new molecule with secreto-dynamic activity: nesosteine]. Clin Ter. 1989 Jan 31;128(2):87-97. Italian. PubMed PMID: 2523778.
6: Luini W, Sozzani S, D'Alessandro F, Zhang HX, Spreafico F. Stimulation of natural host defence mechanisms in rodents by nesosteine. Int J Immunopharmacol. 1988;10(1):59-65. PubMed PMID: 3366510.
7: Girometta MA, Loschi L, Ventura P. High-performance liquid chromatographic assay of nesosteine in human plasma and urine. J Chromatogr. 1989 Jan 27;487(1):117-24. PubMed PMID: 2715254.
8: Mbuyamba P. Clinical trial with CO-1177: a preliminary report. Int J Clin Pharmacol Res. 1986;6(2):119-21. PubMed PMID: 3522442.