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Nifurpirinol
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WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H584851

CAS#: 13411-16-0

Description: Nifurpirinol is a nitroaromatic antibiotic.

Chemical Structure

Nifurpirinol

CAS# 13411-16-0

Instruction

Theoretical Analysis

Hodoodo Cat#: H584851
Name: Nifurpirinol
CAS#: 13411-16-0
Chemical Formula: C12H10N2O4
Exact Mass: 246.06
Molecular Weight: 246.222
Elemental Analysis: C, 58.54; H, 4.09; N, 11.38; O, 25.99

Price and Availability

Size	Price	Availability
5mg	USD 550	2 Weeks
10mg	USD 950	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. Hodoodo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Nifurpirinol; P 7138; P-7138

IUPAC/Chemical Name: 2-Pyridinemethanol, 6-(2-(5-nitro-2-furanyl)ethenyl)-

InChi Key: JQKHJQJVKRFMCO-SNAWJCMRSA-N

InChi Code: InChI=1S/C12H10N2O4/c15-8-10-3-1-2-9(13-10)4-5-11-6-7-12(18-11)14(16)17/h1-7,15H,8H2/b5-4+

SMILES Code: OCC1=NC(/C=C/C2=CC=C([N+]([O-])=O)O2)=CC=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 246.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Tamse CT, Gacutan RQ, Tamse AF. Changes induced in the gills of milkfish (Chanos chanos Forsskål) fingerlings after acute exposure to nifurpirinol (Furanace; P-7138). Bull Environ Contam Toxicol. 1995 Apr;54(4):591-6. PubMed PMID: 7539314.

2: Bergemann D, Massoz L, Bourdouxhe J, Carril Pardo CA, Voz ML, Peers B, Manfroid I. Nifurpirinol: A more potent and reliable substrate compared to metronidazole for nitroreductase-mediated cell ablations. Wound Repair Regen. 2018 Mar;26(2):238-244. doi: 10.1111/wrr.12633. Epub 2018 May 19. PubMed PMID: 29663654.

3: Nakamura Y, Fukushima H, Tomita I, Kimura I. Mutagenicity of nifurpirinol (P-7138) in Escherichia coli WP2 and Salmonella typhimurium TA100. Mutat Res. 1982 Apr;104(1-3):61-6. PubMed PMID: 7043255.

4: Takase Y, Nakamura S, Ishiyama M, Shimizu M. Inhibition of the synthesis of macromolecules in Escherichia coli by nitrofuran derivatives. 3. Nifurpirinol. Chem Pharm Bull (Tokyo). 1973 Jan;21(1):144-8. PubMed PMID: 4576103.

5: Tamse CT, Gacutan RQ. Acute toxicity of nifurpirinol, a fish chemotherapeutant, to milkfish (Chanos chanos) fingerlings. Bull Environ Contam Toxicol. 1994 Mar;52(3):346-50. PubMed PMID: 8142702.

6: Kaufmann A, Butcher P, Maden K, Walker S, Widmer M. Determination of nitrofuran and chloramphenicol residues by high resolution mass spectrometry versus tandem quadrupole mass spectrometry. Anal Chim Acta. 2015 Mar 3;862:41-52. doi: 10.1016/j.aca.2014.12.036. Epub 2014 Dec 24. PubMed PMID: 25682427.

7: Kimura I, Taniguchi N, Kumai H, Tomita I, Kinae N, Yoshizaki K, Ito M, Ishikawa T. Correlation of epizootiological observations with experimental data: chemical induction of chromatophoromas in the croaker, Nibea mitsukurii. Natl Cancer Inst Monogr. 1984 May;65:139-54. PubMed PMID: 6431288.

8: MacMillan JR, Schnick RA, Fornshell G. Stakeholder position paper: aquaculture producer. Prev Vet Med. 2006 Feb 24;73(2-3):197-202. Epub 2005 Nov 9. PubMed PMID: 16289382.

9: Ferguson HW, Moccia RD. Disseminated hexamitiasis in Siamese fighting fish. J Am Vet Med Assoc. 1980 Nov 1;177(9):854-7. PubMed PMID: 7451326.

10: Kimura I, Kinae N, Kumai H, Yamashita M, Nakamura G, Ando M, Ishida H, Tomita I. Environment: peculiar pigment cell neoplasm in fish. J Invest Dermatol. 1989 May;92(5 Suppl):248S-254S. PubMed PMID: 2715659.

11: Nose N, Hoshino Y, Kikuchi Y, Horie M, Saitoh K, Kawachi T, Nakazawa H. Simultaneous liquid chromatographic determination of residual synthetic antibacterials in cultured fish. J Assoc Off Anal Chem. 1987 Jul-Aug;70(4):714-7. PubMed PMID: 3624182.

12: Angelini NM, Seigneur GN. [Disease of the fins of Rhamdia sapo. Isolation of the etiological agents and experimental infection]. Rev Argent Microbiol. 1988 Jan-Mar;20(1):37-48. Spanish. PubMed PMID: 3140294.