WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H565070
CAS#: 1224942-06-6
Description: Jak2-IN-7j is a selective Jak2 inhibitor which demonstrates a time-dependent knock-down of pSTAT5, which is a downstream target of Jak2.
Hodoodo Cat#: H565070
Name: Jak2-IN-7j
CAS#: 1224942-06-6
Chemical Formula: C17H13Cl2N7O
Exact Mass: 401.06
Molecular Weight: 402.240
Elemental Analysis: C, 50.76; H, 3.26; Cl, 17.63; N, 24.38; O, 3.98
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Synonym: Jak2 IN-7j; Jak2 IN 7j; Jak2-IN 7j
IUPAC/Chemical Name: 5-Amino-N-(3-(2,5-dichlorophenyl)-1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
InChi Key: NNGCTIVKZKXWGS-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H13Cl2N7O/c1-25-8-13(15(24-25)10-6-9(18)2-3-12(10)19)22-17(27)11-7-21-26-5-4-14(20)23-16(11)26/h2-8H,1H3,(H2,20,23)(H,22,27)
SMILES Code: O=C(C1=C2N=C(N)C=CN2N=C1)NC3=CN(C)N=C3C4=CC(Cl)=CC=C4Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
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The following data is based on the product molecular weight 402.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |