WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H565136
CAS#: 2173005-10-0 (HCl)
Description: R-IMPP Hydrochloride is an anti-secretagogin of PCSK9, promoting uptake of LDL-C in hepatoma cells by increasing LDL-R levels and blocking PCSK9 translation.
Hodoodo Cat#: H565136
Name: R-IMPP HCl
CAS#: 2173005-10-0 (HCl)
Chemical Formula: C24H28ClN3O2
Exact Mass: 0.00
Molecular Weight: 425.960
Elemental Analysis: C, 67.67; H, 6.63; Cl, 8.32; N, 9.87; O, 7.51
Related CAS #: 2133832-83-2 (free base)
Synonym: R-IMPP Hydrochloride; R IMPP Hydrochloride; RIMPP Hydrochloride; R-IMPP HCl
IUPAC/Chemical Name: (R)-N-(Isoquinolin-1-yl)-3-(4-methoxyphenyl)-N-(piperidin-3-yl)propanamide Hydrochloride
InChi Key: OSIRDWNTKGVIOE-VEIFNGETSA-N
InChi Code: InChI=1S/C24H27N3O2.ClH/c1-29-21-11-8-18(9-12-21)10-13-23(28)27(20-6-4-15-25-17-20)24-22-7-3-2-5-19(22)14-16-26-24;/h2-3,5,7-9,11-12,14,16,20,25H,4,6,10,13,15,17H2,1H3;1H/t20-;/m1./s1
SMILES Code: O=C(N(C1=NC=CC2=C1C=CC=C2)[C@H]3CNCCC3)CCC4=CC=C(OC)C=C4.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 425.96 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
