WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H565586
CAS#: N/A
Description: YZ129 is a novel hsp90 inhibitor, targeting the calcineurin-nfat signaling and hsp90 client network for glioblastoma (gbm) therapy
Hodoodo Cat#: H565586
Name: YZ129
CAS#: N/A
Chemical Formula: C19H12N2O2
Exact Mass: 300.09
Molecular Weight: 300.317
Elemental Analysis: C, 75.99; H, 4.03; N, 9.33; O, 10.65
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Synonym: YZ129; YZ 129; YZ-129
IUPAC/Chemical Name: 4-(Isoquinolin-6-ylamino)naphthalene-1,2-dione
InChi Key: NYDMVPHEEBVAHT-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H12N2O2/c22-18-10-17(15-3-1-2-4-16(15)19(18)23)21-14-6-5-13-11-20-8-7-12(13)9-14/h1-11,21H
SMILES Code: O=C1C(C=C(NC2=CC3=C(C=NC=C3)C=C2)C4=C1C=CC=C4)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 300.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Liu Z, Li H, He L, Xiang Y, Tian C, Li C, Tan P, Jing J, Tian Y, Du L, Huang Y, Han L, Li M, Zhou Y. Discovery of Small-Molecule Inhibitors of the HSP90-Calcineurin-NFAT Pathway against Glioblastoma. Cell Chem Biol. 2019 Mar 21;26(3):352-365.e7. doi: 10.1016/j.chembiol.2018.11.009. Epub 2019 Jan 10. PubMed PMID: 30639261; PubMed Central PMCID: PMC6430684.