WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H573895
CAS#: 635-05-2 (naphthoate)
Description: Pamaquine naphthoate is an 8-aminoquinoline drug formerly used for the treatment of malaria.
Hodoodo Cat#: H573895
Name: Pamaquine naphthoate
CAS#: 635-05-2 (naphthoate)
Chemical Formula: C42H45N3O7
Exact Mass: 703.33
Molecular Weight: 703.840
Elemental Analysis: C, 71.67; H, 6.44; N, 5.97; O, 15.91
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Related CAS #: 63680-62-6 (HCl); 635-05-2 (naphthoate); 491-92-9 (free base)
Synonym: Aminoquin naphthoate, Beprochine naphthoate, Gamefar naphthoate, Pamaquine embonate, Pamaquine naphthoate , Plasmoquine naphthoate
IUPAC/Chemical Name: 2-Naphthoic acid, 4,4'-methylenebis(3-hydroxy-, compd. with 8-((4-(diethylamino)-1-methylbutyl)amino)-6-methoxyquinoline (1:1)
InChi Key: IPPMKVWUPMOGFL-UHFFFAOYSA-N
InChi Code: 1S/C23H16O6.C19H29N3O/c24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29;1-5-22(6-2)12-8-9-15(3)21-18-14-17(23-4)13-16-10-7-11-20-19(16)18/h1-10,24-25H,11H2,(H,26,27)(H,28,29);7,10-11,13-15,21H,5-6,8-9,12H2,1-4H3
SMILES Code: c1(c2c(cc(C(O)=O)c1O)cccc2)Cc1c2c(cc(c1O)C(O)=O)cccc2.c1(c2c(cc(c1)OC)cccn2)N[C@@H](CCCN(CC)CC)C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
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The following data is based on the product molecular weight 703.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Sweeney AW, Blackburn CR, Rieckmann KH. Short report: the activity of pamaquine, an 8-aminoquinoline drug, against sporozoite-induced infections of Plasmodium vivax (New Guinea strains). Am J Trop Med Hyg. 2004 Aug;71(2):187-9. PubMed PMID: 15306708.
2: Matsuno T, Hariguchi F, Okamoto T. Anticoccidial activity of 8-aminoquinolines, pamaquine, primaquine and several molecular complexes and salts of pamaquine, against Eimeria tenella, E. necatrix, E. acervulina, E. maxima, and E. brunetti in battery experiments. J Vet Med Sci. 1991 Feb;53(1):13-7. PubMed PMID: 1830767.
3: LOKEN AC, HAYMAKER W. Pamaquine poisoning in man, with a clinicopathologic study of one case. Am J Trop Med Hyg. 1949 May;29(3):341-52. PubMed PMID: 18145865.
