WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H471030
CAS#: Unknown
Description: NED3238 is new highly potent inhibitor of arginase I and II with IC50 values of 1.3 and 8.1 nM, respectively.
Hodoodo Cat#: H471030
Name: NED3238 (HCl)
CAS#: Unknown
Chemical Formula: C17H30BCl2N3O4
Exact Mass: 0.00
Molecular Weight: 422.154
Elemental Analysis: C, 48.37; H, 7.16; B, 2.56; Cl, 16.79; N, 9.95; O, 15.16
This product is not in stock, which may be available by custom synthesis.
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Synonym: NED3238, NED 3238, NED-3238
IUPAC/Chemical Name: (3R,4S)-3-amino-1-((S)-2-amino-3-phenylpropyl)-4-(3-boronopropyl)pyrrolidine-3-carboxylic acid dihydrochloride
InChi Key: YLRFCKXLPZIAMP-DQZPFBHVSA-N
InChi Code: InChI=1S/C17H28BN3O4.2ClH/c19-15(9-13-5-2-1-3-6-13)11-21-10-14(7-4-8-18(24)25)17(20,12-21)16(22)23;;/h1-3,5-6,14-15,24-25H,4,7-12,19-20H2,(H,22,23);2*1H/t14-,15-,17-;;/m0../s1
SMILES Code: O=C([C@]1(N)CN(C[C@@H](N)CC2=CC=CC=C2)C[C@@H]1CCCB(O)O)O.[H]Cl.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 422.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Van Zandt MC, et al. Discovery of N-Substituted 3-Amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic Acids as Highly Potent Third-Generation Inhibitors of Human Arginase I and II. J Med Chem. 2019 Aug 23.