WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H585137
CAS#: 28402-17-7
Description: WR 77913 is a radioprotective agent.
Hodoodo Cat#: H585137
Name: WR 77913
CAS#: 28402-17-7
Chemical Formula: C3H9NNaO4PS
Exact Mass: 208.99
Molecular Weight: 209.132
Elemental Analysis: C, 17.23; H, 4.34; N, 6.70; Na, 10.99; O, 30.60; P, 14.81; S, 15.33
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: WR 77913; WR77913; WR-77913
IUPAC/Chemical Name: Phosphorothioic acid, S-(3-amino-2-hydroxypropyl) ester, monosodium salt
InChi Key: UCTDNAFCGZFXLP-DFWYDOINSA-M
InChi Code: InChI=1S/C3H10NO4PS.Na/c4-1-3(5)2-8-9(6,7)10;/h3,5H,1-2,4H2,(H2,6,7,10);/q;+1/p-1/t3-;/m0./s1
SMILES Code: [O-]P(OC[C@@H](O)CN)(O)=S.[Na+]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 209.13 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Spence AM, Krohn KA, Steele JE, Edmondson SE, Rasey JS. WR-2721, WR-77913 and WR-3689 radioprotection in the rat spinal cord. Pharmacol Ther. 1988;39(1-3):89-91. PubMed PMID: 2849135.
2: Rasey JS, Magee S, Nelson N, Chin L, Krohn KA. Response of mouse tissues to neutron and gamma radiation: protection by WR-3689 and WR-77913. Radiother Oncol. 1990 Feb;17(2):167-73. PubMed PMID: 2157242.
3: Mendiondo OA, Connor AM, Grigsby P. Sodium hydrogen-S-(3-amino-2-hydroxypropyl) phosphorothioate (WR-77913): toxicity and bone marrow radioprotection. Int J Radiat Oncol Biol Phys. 1982 Mar-Apr;8(3-4):553-5. PubMed PMID: 6286552.
4: Menard TW, Osgood TB, Clark JI, Spence AM, Steele JE, Krohn KA, Livesey JC. Radioprotection against cataract formation by WR-77913 in gamma-irradiated rats. Int J Radiat Oncol Biol Phys. 1986 Aug;12(8):1483-6. PubMed PMID: 3019964.
5: Clark JI, Livesey JC, Steele JE. Delay or inhibition of rat lens opacification using pantethine and WR-77913. Exp Eye Res. 1996 Jan;62(1):75-84. PubMed PMID: 8674515.
6: Remé CE, Braschler UF, Roberts J, Dillon J. Light damage in the rat retina: effect of a radioprotective agent (WR-77913) on acute rod outer segment disk disruptions. Photochem Photobiol. 1991 Jul;54(1):137-42. PubMed PMID: 1658823.
7: Mendiondo OA, Connor AM, Grigsby P. Toxicity and radiation protective effect of WR-77913 in BALB/c mice. Acta Radiol Oncol. 1982;21(5):319-23. PubMed PMID: 6297251.
8: Livesey JC, Wiens LW, Von Seggern DJ, Barlow WE, Arnold AM. Inhibition of radiation cataractogenesis by WR-77913. Radiat Res. 1995 Jan;141(1):99-104. PubMed PMID: 7997522.
9: Dillon J, Kennedy JC, Pottier RH, Roberts JE. In vitro and in vivo protection against phototoxic side effects of photodynamic therapy by radioprotective agents WR-2721 and WR-77913. Photochem Photobiol. 1988 Aug;48(2):235-8. PubMed PMID: 2851844.
10: Lam TT, Liu D, Brody MA, Chu R, Tso MO. Clearance of S-(3-amino-2-hydroxypropyl) phosphorothioate (WR-77913) in rats. Exp Eye Res. 1991 Jun;52(6):661-7. PubMed PMID: 1649765.
11: Osgood TB, Menard TW, Clark JI, Krohn KA. Inhibition of lens opacification in x-irradiated rats treated with WR-77913. Invest Ophthalmol Vis Sci. 1986 Dec;27(12):1780-4. PubMed PMID: 3025129.
12: Bhanumathi P, Devi PU. Modulation of glutathione depletion and lipid peroxidation by WR-77913 an 2-mercaptopropionylglycine in cyclophosphamide chemotherapy. Indian J Exp Biol. 1994 Aug;32(8):562-4. PubMed PMID: 7959938.
13: Clark JI, Steele JE. Phase-separation inhibitors and prevention of selenite cataract. Proc Natl Acad Sci U S A. 1992 Mar 1;89(5):1720-4. PubMed PMID: 1311849; PubMed Central PMCID: PMC48524.
14: Roberts JE, Kinley JS, Young AR, Jenkins G, Atherton SJ, Dillon J. In vivo and photophysical studies on photooxidative damage to lens proteins and their protection by radioprotectors. Photochem Photobiol. 1991 Jan;53(1):33-8. PubMed PMID: 1851303.
15: Rasey JS, Krohn KA, Magee S, Nelson N, Chin L. Comparison of the protective effects of three phosphorothioate radioprotectors in the RIF-1 tumor. Radiat Res. 1986 Nov;108(2):167-75. PubMed PMID: 3024202.
16: Clark JI, Osgood TB, Trask SJ. Inhibition of phase separation by reagents that prevent X-irradiation cataract in vivo. Exp Eye Res. 1987 Dec;45(6):961-7. PubMed PMID: 2828097.
17: Rasey JS, Krohn KA, Menard TW, Spence AM. Comparative biodistribution and radioprotection studies with three radioprotective drugs in mouse tumors. Int J Radiat Oncol Biol Phys. 1986 Aug;12(8):1487-90. PubMed PMID: 3019965.
18: Sigdestad CP, Connor AM, Scott RM. Effect of chemical protectors on the response of the intestine to roentgen or fission neutron irradiation. Acta Radiol Ther Phys Biol. 1976 Oct;15(5):401-9. PubMed PMID: 1007943.
19: Reddy VN, Ikebe H, Giblin FJ, Clark JI, Livesey JC. Effect of radioprotective agents on X-ray cataracts. Lens Eye Toxic Res. 1989;6(4):573-88. Review. PubMed PMID: 2562120.
20: Bedwell J, Chatlani PT, MacRobert AJ, Roberts JE, Barr H, Dillon J, Bown SG. Enhanced tumour selectivity of photodynamic therapy in the rat colon using a radioprotective agent. Photochem Photobiol. 1991 Jun;53(6):753-6. PubMed PMID: 1653426.
