WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H573992
CAS#: 97469-12-0
Description: α-methyl Serotonin (maleate) is an agonist of serotonin (5-HT) receptors. It binds selectively to 5-HT1A, 5-HT1B, 5-HT1C, and 5-HT1D receptors over 5-HT1E receptors. It is also selective for 5-HT2B and 5-HT2C receptors over 5-HT2A receptors. α-methyl Serotonin potentiates motor neuron depolarizations induced by NMDA in the presence of the NMDA receptor antagonist memantine. It also increases dopamine release in a dose-dependent manner. α-methyl Serotonin increases systolic blood pressure and transiently increases heart rate.
Hodoodo Cat#: H573992
Name: α-methyl Serotonin (maleate)
CAS#: 97469-12-0
Chemical Formula: C15H18N2O5
Exact Mass: 306.12
Molecular Weight: 306.320
Elemental Analysis: C, 58.82; H, 5.92; N, 9.15; O, 26.12
Synonym: α-Me-5-HT, α-methyl Serotonin (maleate), α-Methyl-5-HT, α-Methyl-5-hydroxytryptamine, α-Methylserotonin
IUPAC/Chemical Name: 3-(2-aminopropyl)-1H-indol-5-ol, (2Z)-2-butenedioate
InChi Key: YQNHFSXRABPJLP-BTJKTKAUSA-N
InChi Code: InChI=1S/C11H14N2O.C4H4O4/c1-7(12)4-8-6-13-11-3-2-9(14)5-10(8)11;5-3(6)1-2-4(7)8/h2-3,5-7,13-14H,4,12H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
SMILES Code: OC1=CC=C2C(C(CC(C)N)=CN2)=C1.OC(/C=C\C(O)=O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 306.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1. Ismaiel, A.M., Titeler, M., Miller, K.J., et al. 5-HT1 and 5-HT2 binding profiles of the serotonergic agents α-methylserotonin and 2-methylserotonin. J. Med. Chem. 33(2), 755-758 (1990).
2. Baxter, G., Kennett, G., Blaney, F., et al. 5-HT2 receptor subtypes: A family re-united? Trends Pharmacol. Sci. 16(3), 105-110 (1995).
3. Holohean, A.M., and Hackman, J.C. Mechanisms intrinsic to 5-HT2B receptor-induced potentiation of NMDA receptor responses in frog motoneurones. Br. J. Pharmacol. 143(3), 351-360 (2004).
4. Santiago, M., Matarredona, E.R., Machado, A., et al. Influence of serotoninergic drugs on in vivo dopamine extracellular output in rat striatum. J. Neurosci. Res. 52(5), 591-598 (1998).
5. Wilson, H., Coffman, W.J., and Cohen, M.L. 5-Hydroxytryptamine3 receptors mediate tachycardia in conscious instrumented dogs. J. Pharmacol. Exp. Ther. 252(2), 683-688 (1990).
