Quazinone
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    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H471035

CAS#: 70018-51-8

Description: Quazinone, is a phosphodiesterase 3 (PDE3) inhibitor and novel cardiotonic agent with vasodilating properties.

Chemical Structure

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Quazinone
CAS# 70018-51-8
Instruction

Theoretical Analysis

Hodoodo Cat#: H471035
Name: Quazinone
CAS#: 70018-51-8
Chemical Formula: C11H10ClN3O
Exact Mass: 235.05
Molecular Weight: 235.671
Elemental Analysis: C, 56.06; H, 4.28; Cl, 15.04; N, 17.83; O, 6.79

Price and Availability

Size Price Availability Quantity
10mg USD 250 2 Weeks
25mg USD 480 2 Weeks
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Synonym: Quazinone; Ro 13-6438

IUPAC/Chemical Name: (3R)-6-chloro-1,5-dihydro-3-methyl-imidazo[2,1-b]quinazolin-2(3H)-one

InChi Key: BHZFZYLBVSWUMT-ZCFIWIBFSA-N

InChi Code: InChI=1S/C11H10ClN3O/c1-6-10(16)14-11-13-9-4-2-3-8(12)7(9)5-15(6)11/h2-4,6H,5H2,1H3,(H,13,14,16)/t6-/m1/s1

SMILES Code: O=C1NC2=NC3=C(C(Cl)=CC=C3)CN2[C@@H]1C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO and Ethanol

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO and Ethanol

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 235.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Lau, H. Y. A., et al.: Inflamm. Res., 54, S5-S6 (2005); Rickards, K. J., et al.: J. Vet. Pharmacol. Ther., 26, 277 (2003)

2. Osinski, M.T., and Schrör, K. Inhibition of platelet-derived growth factor-induced mitogenesis by phosphodiesterase 3 inhibitors: Role of protein kinase A in vascular smooth muscle cell mitogenesis. Biochem. Pharmacol. 60(3), 381-387 (2000).

3. Taher, A., Meyer, M., Stief, C.G., et al. Cyclic nucleotide phosphodiesterase in human cavernous smooth muscle. World J. Urol. 15(1), 32-35 (1997).

4. Eigenmann, R., Gerold, M., and Holck, M. Cardiovascular profile of Ro 13-6438, a novel positive inotropic agent with vasodilating properties. J. Cardiovasc. Pharmacol. 6(3), 511-519 (1984)