Squalene
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Hodoodo CAT#: H574139

CAS#: 111-02-4

Description: Squalene is a biosynthetic precursor to all steroids. An oil-in-water emulsion of squalene synergistically increases adaptive immune responses to glucopyranosyl lipid adjuvant (GLA), a toll-like receptor 4 (TLR4) agonist, compared with an aqueous formulation of GLA. Formulations containing squalene have been used as adjuvants in vaccines and as hair and skin conditioning agents.

Chemical Structure

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Squalene
CAS# 111-02-4
Instruction

Theoretical Analysis

Hodoodo Cat#: H574139
Name: Squalene
CAS#: 111-02-4
Chemical Formula: C30H50
Exact Mass: 410.39
Molecular Weight: 410.730
Elemental Analysis: C, 87.73; H, 12.27

Price and Availability

Size Price Availability Quantity
50g USD 205
100g USD 330
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Synonym: Spinacene, Squalene, trans-Squalene

IUPAC/Chemical Name: (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosahexaene

InChi Key: YYGNTYWPHWGJRM-AAJYLUCBSA-N

InChi Code: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+

SMILES Code: C/C(C)=C/CC/C(C)=C/CC/C(C)=C/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/C

Appearance: Oil

Purity: >95% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 410.73 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Tansey, T.R., and Shechter, I. Structure and regulation of mammalian squalene synthase. Biochim. Biophys. Acta. 1529(1-3), 49-62 (2000).

2. Kubota, B. The chemical composition of squalene. Tokyo Kagaku Kaishi 39, 879-907 (1918).

3. Seydoux, E., Liang, H., Dubois Cauwelaert, N., et al. Effective combination adjuvants engage both TLR and inflammasome pathways to promote potent adaptive immune responses. J. Immunol. 201(1), 98-112 (2018).