WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H574177
CAS#: 106803-22-9
Description: Deethylindanomycin is a polyether antibiotic that is active against a variety of Gram-positive bacteria, including various strains of S. aureus and Streptococcus, as well as one strain of S. pneumoniae. It is also active against coccidia in vitro, inhibiting E. tenella development, but is inactive against E. tenella infection in chicks when. Deethylindanomycin acts as an ionophore in lipid bilayer membranes and is more selective for potassium ions than calcium, magnesium, and sodium ions. It induces histamine release from rodent mast cells and human basophils in vitro in a calcium-dependent manner.
Hodoodo Cat#: H574177
Name: Deethylindanomycin
CAS#: 106803-22-9
Chemical Formula: C29H39NO4
Exact Mass: 465.29
Molecular Weight: 465.630
Elemental Analysis: C, 74.81; H, 8.44; N, 3.01; O, 13.74
Synonym: 16-Deethylindanomycin, A 83094A, Deethylindanomycin, Omomycin
IUPAC/Chemical Name: (R)-2-((2R,5S,6R)-6-((3E,5E)-6-((3aR,4S,5R,7aS)-4-(1H-pyrrole-2-carbonyl)-2,3,3a,4,5,7a-hexahydro-1H-inden-5-yl)hexa-3,5-dien-3-yl)-5-methyltetrahydro-2H-pyran-2-yl)propanoic acid
InChi Key: HSZFOQSMGNAIJM-HXLIROMVSA-N
InChi Code: InChI=1S/C29H39NO4/c1-4-20(28-18(2)13-16-25(34-28)19(3)29(32)33)8-5-10-22-15-14-21-9-6-11-23(21)26(22)27(31)24-12-7-17-30-24/h5,7-8,10,12,14-15,17-19,21-23,25-26,28,30H,4,6,9,11,13,16H2,1-3H3,(H,32,33)/b10-5+,20-8+/t18-,19+,21-,22+,23+,25+,26+,28+/m0/s1
SMILES Code: O=C(C1=CC=CN1)[C@H]2[C@@]3([H])[C@](CCC3)([H])C=C[C@H]2/C=C/C=C(CC)/[C@@H]4O[C@]([C@@H](C)C(O)=O)([H])CC[C@@H]4C
Appearance: Solid powder
Purity: >95% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 465.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1. Zebrev, A.I., Antonenko, Y.N., Gushchin, I.S., et al. Ionophore properties and histamine-releasing action of the polyether antibiotic omomycin (985-I). Biol. Membrany 3(12), 1224-1231 (1986).
2. Larsen, S.H., Boeck, L.D., Mertz, F.P., et al. 16-Deethylindanomycin (A83094A), a novel pyrrole-ether antibiotic produced by a strain of Streptomyces setonii. Taxonomy, fermentation, isolation and characterization. J. Antibiot. (Tokyo) 41(9), 1170-1177 (1988).
