WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H585423
CAS#: 82147-31-7
Description: WR 151327 increases resistance to Klebsiella pneumoniae infection in mixed-field- and gamma-photon-irradiated immunocompromised mice.
Hodoodo Cat#: H585423
Name: WR 151327
CAS#: 82147-31-7
Chemical Formula: C7H19N2O3PS
Exact Mass: 242.09
Molecular Weight: 242.274
Elemental Analysis: C, 34.70; H, 7.91; N, 11.56; O, 19.81; P, 12.78; S, 13.23
This product is not in stock, which may be available by custom synthesis.
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Synonym: WR 151327; WR151327; WR-151327
IUPAC/Chemical Name: 3-[3-(methylamino)propylamino]propylsulfanylphosphonic acid
InChi Key: RJCFTKZFLQWQQX-UHFFFAOYSA-N
InChi Code: InChI=1S/C7H19N2O3PS/c1-8-4-2-5-9-6-3-7-14-13(10,11)12/h8-9H,2-7H2,1H3,(H2,10,11,12)
SMILES Code: OP(SCCCNCCCNC)(O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 242.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Steel LK, Jacobs AJ, Giambarresi LI, Jackson WE 3rd. Protection of mice against fission neutron irradiation by WR-2721 or WR-151327. Radiat Res. 1987 Mar;109(3):469-78. PubMed PMID: 3031721.
2: Grdina DJ, Garnes BA, Nagy B. Protection by WR-2721 and WR-151327 against late effects of gamma rays and neutrons. Adv Space Res. 1992;12(2-3):257-63. PubMed PMID: 11537016.
3: Sigdestad CP, Grdina DJ, Connor AM, Hanson WR. A comparison of radioprotection from three neutron sources and 60Co by WR-2721 and WR-151327. Radiat Res. 1986 May;106(2):224-33. PubMed PMID: 3010368.
4: Kalebic T, Schein PS. Organic thiophosphate WR-151327 suppresses expression of HIV in chronically infected cells. AIDS Res Hum Retroviruses. 1994 Jun;10(6):727-33. PubMed PMID: 7521193.
5: Landauer MR, Castro CA, Benson KA, Hogan JB, Weiss JF. Radioprotective and locomotor responses of mice treated with nimodipine alone and in combination with WR-151327. J Appl Toxicol. 2001 Jan-Feb;21(1):25-31. PubMed PMID: 11180277.
6: Matsushita S, Ando K, Koike S, Grdina DJ, Furukawa S. Radioprotection by WR-151327 against the late normal tissue damage in mouse hind legs from gamma ray radiation. Int J Radiat Oncol Biol Phys. 1994 Nov 15;30(4):867-72. PubMed PMID: 7960989.
7: Ledney GD, Elliott TB, Harding RA, Jackson WE 3rd, Inal CE, Landauer MR. WR-151327 increases resistance to Klebsiella pneumoniae infection in mixed-field- and gamma-photon-irradiated mice. Int J Radiat Biol. 2000 Feb;76(2):261-71. PubMed PMID: 10716647.
8: Vaishnav YN, Pendergrass JA Jr, Clark EP, Swenberg CE. Chromatographic and mass spectral analysis of the radioprotector and chemoprotector S-3-(3-methylaminopropylamino)propanethiol (WR-151326) and its symmetrical disulfide (WR-25595501). J Pharm Biomed Anal. 1996 Jan;14(3):317-24. PubMed PMID: 8851756.
9: Ledney GD, Elliott TB, Landauer MR, Vigneulle RM, Henderson PL, Harding RA, Tom SP Jr. Survival of irradiated mice treated with WR-151327, synthetic trehalose dicorynomycolate, or ofloxacin. Adv Space Res. 1994 Oct;14(10):583-6. PubMed PMID: 11539995.
10: Green D, Bensely D, Schein P. Preclinical evaluation of WR-151327: an orally active chemotherapy protector. Cancer Res. 1994 Feb 1;54(3):738-41. PubMed PMID: 8306335.
11: van Beek ME, Doak RL, Sigdestad CP, Grdina DJ. Pathological effects of the radiation protector WR-151327 in mice. Radiat Res. 1990 Oct;124(1):79-84. PubMed PMID: 2236499.
12: Steel-Goodwin L, Kendrick JM, Egan JE, Eckstein JM. Pathological evaluation of WR-151327 administered orally in irradiated and non-irradiated male mice. Ann Clin Lab Sci. 1992 May-Jun;22(3):182-8. PubMed PMID: 1503385.
13: Grdina DJ, Wright BJ, Carnes BA. Protection by WR-151327 against late-effect damage from fission-spectrum neutrons. Radiat Res. 1991 Oct;128(1 Suppl):S124-7. PubMed PMID: 1924738.
14: Ledney GD, Elliott TB. Combined injury: factors with potential to impact radiation dose assessments. Health Phys. 2010 Feb;98(2):145-52. doi: 10.1097/01.HP.0000348466.09978.77. PubMed PMID: 20065676.
15: Weiss JF. Pharmacologic approaches to protection against radiation-induced lethality and other damage. Environ Health Perspect. 1997 Dec;105 Suppl 6:1473-8. Review. PubMed PMID: 9467066; PubMed Central PMCID: PMC1469917.
16: Weiss JF, Landauer MR. Radioprotection by antioxidants. Ann N Y Acad Sci. 2000;899:44-60. Review. PubMed PMID: 10863528.
17: Paunesku D, Paunesku T, Wahl A, Kataoka Y, Murley J, Grdina DJ, Woloschak GE. Incidence of tissue toxicities in gamma ray and fission neutron-exposed mice treated with Amifostine. Int J Radiat Biol. 2008 Aug;84(8):623-34. doi: 10.1080/09553000802241762. PubMed PMID: 18661379.
18: Steel-Goodwin L, Egan JE, Kendrick JM, Jackson WE, Heman-Ackah LM, Eckstein JM. Comparative intestinal and testes toxicity of four aminothiols in irradiated and nonirradiated mice. Ann Clin Lab Sci. 1993 Nov-Dec;23(6):439-47. PubMed PMID: 8291898.
19: Sigdestad CP, Connor AM, Sims CS. Modification of neutron-induced hematopoietic effects by chemical radioprotectors. Int J Radiat Oncol Biol Phys. 1992;22(4):807-11. PubMed PMID: 1544854.
20: Ando K. [Chemical radioprotectors]. Gan No Rinsho. 1987 Oct;33(13):1679-83. Japanese. PubMed PMID: 2826838.
