WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H585446
CAS#: Zandelisib mesylate
Description: Zandelisib, also known as PWT143 and ME-401, is an orally bioavailable inhibitor of the delta isoform of phosphatidylinositide 3-kinase (PI3K), with potential antineoplastic activity. Upon oral administration, PI3K-delta inhibitor PWT143 selectively inhibits the delta isoform of PI3K and prevents the activation of the PI3K/AKT signaling pathway. This both decreases proliferation and induces cell death in PI3K-delta-overexpressing tumor cells. PI3K-delta plays a key role in the proliferation and survival of hematologic cancer cells. The targeted inhibition of PI3K-delta is designed to preserve PI3K signaling in normal, non-neoplastic cells. PI3K, an enzyme often overexpressed in cancer cells, plays a crucial role in tumor cell regulation and survival.
Hodoodo Cat#: H585446
Name: Zandelisib mesylate
CAS#: Zandelisib mesylate
Chemical Formula: C32H42F2N8O4S
Exact Mass: 576.31
Molecular Weight: 672.797
Elemental Analysis: C, 57.13; H, 6.29; F, 5.65; N, 16.66; O, 9.51; S, 4.77
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Related CAS #: 1595129-71-7 (free base) Zandelisib HCl Zandelisib mesylate,
Synonym: PWT143; PWT-143; PWT 143; ME-401; ME401; ME 401; Zandelisib; Zandelisib mesylate
IUPAC/Chemical Name: 4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-{2-methyl-1-[2-(1-methylpiperidin-4-yl)phenyl]propan-2-yl}-6-(morpholin- 4-yl)-1,3,5-triazin-2-amine mesylate
InChi Key: VPALCEHSOCBDNH-UHFFFAOYSA-N
InChi Code: InChI=1S/C31H38F2N8O.CH4O3S/c1-31(2,20-22-8-4-5-9-23(22)21-12-14-39(3)15-13-21)38-28-35-29(40-16-18-42-19-17-40)37-30(36-28)41-25-11-7-6-10-24(25)34-27(41)26(32)33;1-5(2,3)4/h4-11,21,26H,12-20H2,1-3H3,(H,35,36,37,38);1H3,(H,2,3,4)
SMILES Code: CC(NC1=NC(N2C3=CC=CC=C3N=C2C(F)F)=NC(N4CCOCC4)=N1)(C)CC5=CC=CC=C5C6CCN(C)CC6.OS(=O)(C)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 672.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |