WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H555771
CAS#: 2230211-82-0
Description: ATX-081 is an ionizable cationic lipids for RNA or Gene delivery.
Hodoodo Cat#: H555771
Name: ATX-081
CAS#: 2230211-82-0
Chemical Formula: C37H70N2O5S
Exact Mass: 654.50
Molecular Weight: 655.036
Elemental Analysis: C, 67.84; H, 10.77; N, 4.28; O, 12.21; S, 4.89
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Synonym: ATX-081; ATX 081; ATX081;
IUPAC/Chemical Name: (2Z)-2-Nonen-1-yl 4-[[[[2-(dimethylamino)ethyl]thio]carbonyl][4-[(1-heptyloctyl)oxy]-4-oxobutyl]amino]butanoate
InChi Key: XSWXHOQMWXTMEH-QOCHGBHMSA-N
InChi Code: InChI=1S/C37H70N2O5S/c1-6-9-12-15-16-19-22-32-43-35(40)27-23-29-39(37(42)45-33-31-38(4)5)30-24-28-36(41)44-34(25-20-17-13-10-7-2)26-21-18-14-11-8-3/h19,22,34H,6-18,20-21,23-33H2,1-5H3/b22-19-
SMILES Code: CCCCCC/C=C\COC(CCCN(CCCC(OC(CCCCCCC)CCCCCCC)=O)C(SCCN(C)C)=O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 655.04 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Preparation of ionizable cationic lipids for RNA delivery
By Payne, Joseph E.; Chivukula, Padmanabh; Tanis, Steven P.; Karmali, Priya
From PCT Int. Appl. (2018), WO 2018119163 A1 20180628.