WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H593187
CAS#: 2230496-93-0
Description: ZL0516 is a is a chromone derivatives used as orally bioavailable BRD4-selective inhibitor. This BRD4 BD1 inhibitor has demonstrated impressive in vivo efficacy and overall promising pharmacokinetic properties, indicating its therapeutic potential for the treatment of inflammatory diseases.
Hodoodo Cat#: H593187
Name: ZL0516
CAS#: 2230496-93-0
Chemical Formula: C27H34N2O6
Exact Mass: 482.24
Molecular Weight: 482.577
Elemental Analysis: C, 67.20; H, 7.10; N, 5.81; O, 19.89
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Synonym: ZL0516; ZL-0516; ZL 0516
IUPAC/Chemical Name: (R)-2-(4-(2-Hydroxy-3-(4-methylpiperazin-1-yl)propoxy)-3,5-dimethylphenyl)-5,7-dimethoxy-4H-chromen-4-one
InChi Key: UDPXIEUTIPNLKC-HXUWFJFHSA-N
InChi Code: InChI=1S/C27H34N2O6/c1-17-10-19(23-14-22(31)26-24(33-5)12-21(32-4)13-25(26)35-23)11-18(2)27(17)34-16-20(30)15-29-8-6-28(3)7-9-29/h10-14,20,30H,6-9,15-16H2,1-5H3/t20-/m1/s1
SMILES Code: O=C1C=C(C2=CC(C)=C(OC[C@H](O)CN3CCN(C)CC3)C(C)=C2)OC4=C1C(OC)=CC(OC)=C4
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 482.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Liu Z, Chen H, Wang P, Li Y, Wold EA, Leonard PG, Joseph S, Brasier AR, Tian B, Zhou J. .Discovery of Orally Bioavailable Chromone Derivatives as Potent and Selective BRD4 Inhibitors: Scaffold Hopping, Optimization, and Pharmacological Evaluation. J Med Chem. doi: 10.1021/acs.jmedchem.0c00035.