1-Hydroxyvaldecoxib

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H462000

CAS#: 181695-81-8

Description: 1-Hydroxyvaldecoxib is a COX-2 inhibitor.

Chemical Structure

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1-Hydroxyvaldecoxib
CAS# 181695-81-8
Instruction

Theoretical Analysis

Hodoodo Cat#: H462000
Name: 1-Hydroxyvaldecoxib
CAS#: 181695-81-8
Chemical Formula: C16H14N2O4S
Exact Mass: 330.07
Molecular Weight: 330.358
Elemental Analysis: C, 58.17; H, 4.27; N, 8.48; O, 19.37; S, 9.70

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: 1-Hydroxyvaldecoxib; SC-66905

IUPAC/Chemical Name: 4-[5-(hydroxymethyl)-3-phenyl-1,2-oxazol-4-yl]benzenesulfonamide

InChi Key: UJSFKTUZOASIPA-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H14N2O4S/c17-23(20,21)13-8-6-11(7-9-13)15-14(10-19)22-18-16(15)12-4-2-1-3-5-12/h1-9,19H,10H2,(H2,17,20,21)

SMILES Code: O=S(C1=CC=C(C2=C(CO)ON=C2C3=CC=CC=C3)C=C1)(N)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 330.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: The Cyclooxigenase-2 Inhibitor Parecoxib Prevents Epidermal Dysplasia in HPV16-Transgenic Mice: Efficacy and Safety Observations Tiago Ferreira, Sandra Campos, Mónica G. Silva, Rita Ribeiro, Susana Santos, José Almeida, Maria João Pires, Rui Miguel Gil da Costa, Cláudia Córdova, António Nogueira, Maria João Neuparth, Rui Medeiros, Margarida Maria da Silva Monteiro Bastos, Isabel Gaivão, Francisco Peixoto, Maria Manuel Oliveira, Paula Alexandra Oliveira Int J Mol Sci. 2019 Aug; 20(16): 3902. Published online 2019 Aug 10. doi: 10.3390/ijms20163902 PMCID: PMC6720853

2: Recent Methodologies toward the Synthesis of Valdecoxib: A Potential 3,4-diarylisoxazolyl COX-2 Inhibitor Sureshbabu Dadiboyena, Adel Nefzi Eur J Med Chem. Author manuscript; available in PMC 2012 Jan 23.Published in final edited form as: Eur J Med Chem. 2010 Nov; 45(11): 4697–4707. Published online 2010 Aug 6. doi: 10.1016/j.ejmech.2010.07.045 PMCID: PMC3263766