WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H574323
CAS#: 2482-25-9
Description: p-Hydroxyhippuric acid is a dihydroxy phenolic acid inhibitor of organic anion transporter 1 (OAT1). It increases the production of free radicals and reduces the secretion of TNF-α, but not IL-1β or IL-6, in isolated human peripheral blood mononuclear cells (PBMCs) stimulated with LPS.
Hodoodo Cat#: H574323
Name: p-Hydroxyhippuric acid
CAS#: 2482-25-9
Chemical Formula: C9H9NO4
Exact Mass: 195.05
Molecular Weight: 195.174
Elemental Analysis: C, 55.39; H, 4.65; N, 7.18; O, 32.79
Synonym: p-Hydroxyhippuric acid, 4-Hydroxyhippuric Acid, para-Hydroxyhippuric Acid
IUPAC/Chemical Name: N-(4-hydroxybenzoyl)-glycine
InChi Key: ZMHLUFWWWPBTIU-UHFFFAOYSA-N
InChi Code: InChI=1S/C9H9NO4/c11-7-3-1-6(2-4-7)9(14)10-5-8(12)13/h1-4,11H,5H2,(H,10,14)(H,12,13)
SMILES Code: OC1=CC=C(C(NCC(O)=O)=O)C=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 195.17 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Motojima, M., Hosokawa, A., Yamato, H., et al. Uraemic toxins induce proximal tubular injury via organic anion transporter 1-mediated uptake. Br. J. Pharmacol. 135(2), 555-563 (2002).
2. Monagas, M., Khan, N., Andrés-Lacueva, C., et al. Dihydroxylated phenolic acids derived from microbial metabolism reduce lipopolysaccharide-stimulated cytokine secretion by human peripheral blood mononuclear cells. Br. J. Nutr. 102(2), 201-206 (2009).