WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H462194
CAS#: 19817-92-6
Description: Uridine 5'-triphosphate sodium salt is a nucleotide and dual agonist of purinergic P2Y2 and P2Y4 receptors.
Hodoodo Cat#: H462194
Name: Uridine 5'-triphosphate sodium salt
CAS#: 19817-92-6
Chemical Formula: C9H12N2Na3O15P3
Exact Mass: 549.91
Molecular Weight: 550.085
Elemental Analysis: C, 19.65; H, 2.20; N, 5.09; Na, 12.54; O, 43.63; P, 16.89
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: Uridine 5'-triphosphate sodium salt; UTP sodium salt
IUPAC/Chemical Name: sodium ((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen triphosphate
InChi Key: MMJGIWFJVDOPJF-LLWADOMFSA-K
InChi Code: InChI=1S/C9H15N2O15P3.3Na/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18;;;/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18);;;/q;3*+1/p-3/t4-,6-,7-,8-;;;/m1.../s1
SMILES Code: O=P(OP(OP(O)([O-])=O)([O-])=O)([O-])OC[C@@H]1[C@@H](O)[C@@H](O)[C@@](N2C(NC(C=C2)=O)=O)([H])O1.[Na+].[Na+].[Na+]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 550.08 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Choi, J.H., Ji, Y.G., and Lee, D.H. Uridine triphosphate increases proliferation of human cancerous pancreatic duct epithelial cells by activating P2Y2 receptor. Pancreas 42(4), 680-686 (2013).
2: Maruoka, H., Jayasekara, M.P.S., Barrett, M.O., et al. Pyrimidine nucleotides with 4-alkyloxyimino and terminal tetraphosphate δ-ester modifications as selective agonists of the P2Y4 receptor. J. Med. Chem. 54(12), 4018-4033 (2011).
3: Matsumoto, T., Nakane, T., and Chiba, S. UTP induces vascular responses in the isolated and perfused canine epicardial coronary artery via UTP-preferring P2Y receptors. Br. J. Pharmacol. 122(8), 1625-1632 (1997).
4: Berg, J.M., Tymoczko, J.L., and Stryer, L. In de novo synthesis, the pyrimidine ring is assembled from bicarbonate, aspartate, and glutamine. Biochemistry (2002).
5: Berg, J.M., Tymoczko, J.L., and Stryer, L. Glycogen is synthesized and degraded by different pathways. Biochemistry (2002).
