SGS-518 oxalate
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Hodoodo CAT#: H574403

CAS#: 445441-27-0

Description: SGS-518 oxalate is a selective antagonist of the 5-HT6 subtype of the serotonin receptor. It may be useful for the treatment of cognitive impairment that is associated with schizophrenia and Alzheimer's disease.

Chemical Structure

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SGS-518 oxalate
CAS# 445441-27-0
Instruction

Theoretical Analysis

Hodoodo Cat#: H574403
Name: SGS-518 oxalate
CAS#: 445441-27-0
Chemical Formula: C23H24F2N2O7S
Exact Mass: 510.13
Molecular Weight: 510.510
Elemental Analysis: C, 54.11; H, 4.74; F, 7.44; N, 5.49; O, 21.94; S, 6.28

Price and Availability

Size Price Availability Quantity
10mg USD 320 2 Weeks
50mg USD 1020 2 Weeks
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Synonym: SGS-518 oxalate

IUPAC/Chemical Name: 1-methyl-3-(1-methylpiperidin-4-yl)-1H-indol-5-yl 2,6-difluorobenzenesulfonate oxalate

InChi Key: XQGFYENETWVJEU-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H22F2N2O3S.C2H2O4/c1-24-10-8-14(9-11-24)17-13-25(2)20-7-6-15(12-16(17)20)28-29(26,27)21-18(22)4-3-5-19(21)23;3-1(4)2(5)6/h3-7,12-14H,8-11H2,1-2H3;(H,3,4)(H,5,6)

SMILES Code: CN2C1=CC=C(OS(C4=C(F)C=CC=C4F)(=O)=O)C=C1C(C3CCN(C)CC3)=C2.OC(C(O)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 510.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Kim et al (2008) New serotonin 5-HT6 ligands from common feature pharmacophore hypotheses. J.Chem.Inf.Model. 48 197 PMID: 18044950

2. Romero et al (2006) Efficacy of selective 5-HT6 receptor ligands determined by monitoring 5-HT6 receptor-mediated cAMP signaling pathways. Br.J.Pharmocol. 148 1133 PMID: 16865095