WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H462228
CAS#: 6298-15-3
Description: PI-083 is a cell-permeable, reversible 20S proteasome inhibitor with IC50 values of 1 µM, 4.5 µM and 4.5 µM for CT-L, T-L and PGPH-L respectively. PI-083 exhibits CT-L (chymotrypsin-like) and cell proliferation inhibition selectively in ovarian, pancreatic, and breast cancer cells (T80-Hras, C7-Kras, and MCF-7, respectively) over their non-transformed counterparts (T80, C7, and MCF-10A), and induction of apoptosis with IC50 values of 3.7 µM in an MTT assay on bone marrow cells isolated from multiple myeloma patients in vitro. PI-083 shown to have anti-tumor activities in a nude mouse xenograft model implanted with MCF-7 and A549 cells in vivo
Hodoodo Cat#: H462228
Name: PI-083
CAS#: 6298-15-3
Chemical Formula: C21H14ClN3O4S
Exact Mass: 439.04
Molecular Weight: 439.870
Elemental Analysis: C, 57.34; H, 3.21; Cl, 8.06; N, 9.55; O, 14.55; S, 7.29
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Synonym: PI-083; PI083; PI 083
IUPAC/Chemical Name: 4-((3-chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)amino)-N-(pyridin-2-yl)benzenesulfonamide
InChi Key: QRPKNPKHGNUFGK-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H14ClN3O4S/c22-18-19(21(27)16-6-2-1-5-15(16)20(18)26)24-13-8-10-14(11-9-13)30(28,29)25-17-7-3-4-12-23-17/h1-12,24H,(H,23,25)
SMILES Code: O=C1C(Cl)=C(NC2=CC=C(S(=O)(NC3=CC=CC=N3)=O)C=C2)C(C4=C1C=CC=C4)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 439.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Kazi A, Lawrence H, Guida WC, et al. Discovery of a novel proteasome inhibitor selective for cancer cells over non-transformed cells. Cell Cycle. 2009;8(12):1940-1951. doi:10.4161/cc.8.12.8798